University Chemistry ›› 2021, Vol. 36 ›› Issue (9): 2107008.doi: 10.3866/PKU.DXHX202107008

Special Issue: 分析化学课程与实验教学

• Between Teacher and Student • Previous Articles     Next Articles

Discussion on the Relationship and Influence Factors of the Limit of Detection and the Sensitivity of Analytical Methods

Honglan Qi(), Jiani Li, Chengxiao Zhang()   

  • Received:2021-06-30 Accepted:2021-07-28 Published:2021-08-19
  • Contact: Honglan Qi,Chengxiao Zhang E-mail:honglanqi@snnu.edu.cn;cxzhang@snnu.edu.cn

Abstract:

The Limit of Detection and Sensitivity of analytical methods are two basic parameters for evaluating analytical methods. The International Union of Pure and Applied Chemistry (IUPAC) clearly recommends their definitions. However, both of them are still somewhat confused in some textbooks and research papers of analytical chemistry. Here, the definitions of both Limit of Detection and Sensitivity are clearly presented and the influence factors on Limit of Detection and Sensitivity of modern analytical methods are discussed. Some strategies to improve the Limit of Detection and the Sensitivity are proposed.

Key words: Limit of Detection, Sensitivity, Standard curve, Analytical chemistry

MSC2000: 

  • G64