大学化学 >> 2023, Vol. 38 >> Issue (11): 171-179.doi: 10.3866/PKU.DXHX202303056

所属专题： 化学实验课程思政建设； 化学实验教学和管理(2023)

化学实验 上一篇    下一篇

肿瘤原位荧光标记技术设计和探索虚拟仿真实验

宦双燕1,*(), 李珂2, 张晓兵1, 罗伟平1, 王玉枝1, 尹霞1, 任天兵1, 高红霞1, 梁志武1   

  1. 1 湖南大学化学化工学院, 长沙 410082
    2 中南大学化学化工学院, 长沙 410083
  • 收稿日期:2023-03-16 录用日期:2023-05-18 发布日期:2023-05-29
  • 通讯作者: 宦双燕 E-mail:syhuan@hnu.edu.cn
  • 基金资助:
    湖南省普通高等学校课程思政建设研究项目(HNKCSZ-2020-0074);湖南省普通高等学校教学改革研究项目(HNJG-2021-0024)

Virtual Simulation Experiment for the Design and Exploration of Tumor in Situ Fluorescence Labeling Technology

Shuangyan Huan1,*(), Ke Li2, Xiaobing Zhang1, Weiping Luo1, Yuzhi Wang1, Xia Yin1, Tianbing Ren1, Hongxia Gao1, Zhiwu Liang1   

  1. 1 College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
    2 College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
  • Received:2023-03-16 Accepted:2023-05-18 Published:2023-05-29
  • Contact: Shuangyan Huan E-mail:syhuan@hnu.edu.cn

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摘要：

原位荧光成像技术为细胞和活体水平生化信息获取提供了强有力的手段，基于固态发光荧光探针的长时间原位标记技术能应用于精准成像与手术导航肿瘤切除。但该科研实验存在周期长、成本高、消耗大等困难，无法引入本科教学。采用U3D三维虚拟现实技术平台将该最新研究成果转化为“肿瘤原位荧光标记技术设计和探索虚拟仿真实验”，通过37步交互操作和基于重要科学问题的探究式教学，培养学生动手能力、科学思维和创新意识，实现科学素养和科研价值观的引导。

关键词: 原位荧光成像, 虚拟仿真实验, 荧光探针, 手术导航

Abstract:

In situ fluorescence imaging technology offers an efficacious method for garnering biochemical information at cellular and organismal scales. Prolonged in situ labeling techniques, using solid-state fluorescent probes, are particularly suited for precise imaging and surgical navigation during tumor resections. However, the inherent challenges, including extended research cycles, high costs, and substantial resource utilization, often preclude their inclusion in undergraduate teaching. To surmount these obstacles, we transformed the latest research findings into a "virtual simulation experiment of tumor in situ fluorescent labeling technology design and exploration" utilizing the U3D three-dimensional virtual reality technology platform. Through an interactive 37-step operation and exploratory teaching approach centred on crucial scientific issues, we aim to hone students' practical skills, foster scientific thinking and innovative awareness, actively guide the development of their scientific literacy, and instil values pertinent to scientific research.

Key words: In situ fluorescence imaging, Virtual simulation experiment, Fluorescent probes, Surgical navigation