利用无溶剂研磨反应制备3-取代异吲哚啉-1-酮类化合物
Synthesis of 3-Substituted Isoindolin-1-ones by Solvent-Free Grinding Reaction
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| 序号 | 碱(摩尔百分比) | 研磨时间/min | 产率 |
| 1 | Et3N (10%) | 5 | 86% |
| 2 | iPr2NEt (10%) | 5 | 85% |
| 3 | DABOC (10%) | 5 | 87% |
| 4 | DBU (10%) | 5 | 86% |
| 5 | PPh3 (10%) | 20 | 0 |
| 6 | NaOH (10%) | 5 | 结果复杂 |
| 7 | Na2CO3 (10%) | 10 | 75% |
| 8 | K2CO3 (10%) | 5 | > 99% |
| 9 | K2CO3 (10%) | 1 | > 99% |
| 10 | K2CO3 (5%) | 10 | 84% |