取代环己酮还原立体选择性的过渡态理论解释

李佳, 胡潇, 王健春, 于凯歌, 耿诗宁, 孟祥福

Explanation of the Transition State Theory of the Stereoselectivity of the Reduction of Substituted Cyclohexanone

Jia Li, Xiao Hu, Jianchun Wang, Kaige Yu, Shining Geng, Xiangfu Meng

表2 烷基格氏试剂与4-叔丁基环己酮的加成反应[5]

格氏试剂 溶剂 轴向产物 赤道向产物 CH3MgI 乙醚 53% 47% CH3MgBr 乙醚 60% 40% CH3MgBr THF 69% 31% CH3MgBr 苯甲醚 61% 39% CH3MgBr 苯 62% 38% CH3MgCl 乙醚 59% 41% n-C3H7MgBr 乙醚 68% 32% i-C3H7MgBr 乙醚 82% 18% t-C4H9MgBr 乙醚 100% 0 C6H5CH2MgBr 乙醚 76% 20%