“铁盐+空气”催化氧化体系在绿色交叉偶联反应中的应用——推荐一个本科生科研训练项目

李若璞, 徐一泽, 胡仁铭, 赖易欢, 徐大振

Application of "Iron Salt + Air" Catalytic Oxidation System in Green Cross Coupling Reaction: Recommendation for an Undergraduate Research-Training Program

Ruopu Li, Yize Xu, Renming Hu, Yihuan Lai, Dazhen Xu

表1 条件优化实验a

Entry Cat (10 mol%) Solvent (mL) T/℃ Time (h) Yield/% b 1 FeCl3 EtOH 80 5 trace 2 FeCl3 CH3CN 80 5 trace 3 FeCl3 DMF 80 5 45 4 FeBr3 DMF 80 6 57 5 Fe(NO3)3∙9H2O DMF 80 6 62 6 Fe(OTf)3 DMF 80 5 21 7 Fe2(SO4)3∙xH2O DMF 80 7 65 8 FeCl2∙4H2O DMF 80 5 54 9 Fe(OAc)2 DMF 80 5 93 10 PhCOOH DMF 80 6 – 11 c Fe(OAc)2 DMF 80 7.5 84 12 – DMF 80 6 –