大学化学 >> 2025, Vol. 40 >> Issue (4): 277-281.doi: 10.12461/PKU.DXHX202407017

所属专题： 有机电化学

知识介绍 上一篇    下一篇

电化学促进硝基芳烃的脱硝基硼化和磺酰氟化反应

曹中艳1, 徐尤智1, 李梦华1, 肖霄3, 孔宪强4, 钱德云2   

  1. 1 河南大学化学与分子科学学院, 河南 开封 475004;
    2 云南大学药学院, 自然资源药物化学教育部重点实验室, 云南省天然产物转化与应用重点实验室, 昆明 650500;
    3 浙江工业大学长三角绿色制药协同创新中心, 杭州 310014;
    4 常州工学院化工与材料学院, 江苏 常州 213032
  • 收稿日期:2024-07-01 录用日期:2024-09-02 发布日期:2025-04-25
  • 通讯作者: 孔宪强, 钱德云 E-mail:kongxq@czu.cn;dyqian@ynu.edu.cn
  • 基金资助:
    国家自然科学基金(22201062, 22372015, 22202021, 22208302, 22101250)；河南大学校级教改项目(HDXJJG-2022-035)

Electrochemically Driven Denitrative Borylation and Fluorosulfonylation of Nitroarenes

Zhongyan Cao1, Youzhi Xu1, Menghua Li1, Xiao Xiao3, Xianqiang Kong4, Deyun Qian2   

  1. 1 College of Chemistry and Molecular Sciences, Henan University, Kaifeng 475004, Henan Province, China;
    2 Yunnan Key Laboratory of Research and Development for Natural Products, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education;School of Pharmacy, Yunnan University, Kunming 650500, China;
    3 Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China;
    4 School of Chemical Engineering and Materials, Changzhou Institute of Technology, Changzhou 213032, Jiangsu Province, China
  • Received:2024-07-01 Accepted:2024-09-02 Published:2025-04-25
  • Contact: Xianqiang Kong, Deyun Qian E-mail:kongxq@czu.cn;dyqian@ynu.edu.cn

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摘要： 硝基芳烃广泛应用于有机合成中，是本科有机化学教学内容的重点之一。温和条件下脱硝基转化的高效方法十分有限。近年来，绿色电合成技术为硝基芳烃C―N键的选择性转化提供了新思路。本文结合学科前沿，选取本科生易于理解的反应实例介绍硝基芳烃脱硝基转化的最新进展，以开阔学生视野、激发学习兴趣、丰富知识储备。

关键词: 硝基芳烃, 脱硝基转化, 电合成, 芳基硼酸酯, 芳基磺酰氟

Abstract: Nitroarenes are widely utilized in organic synthesis and are a key topic in undergraduate organic chemistry curricula. However, efficient methods for denitrative transformations of nitroarenes under mild conditions remain limited. In recent years, green electrochemical synthesis has emerged as a promising approach for the selective C―N bond transformations of nitroarenes. This mini-review highlights recent advances in electrochemically facilitated denitrative transformations of nitroarenes, using reaction examples that are accessible to undergraduate students. These examples aim to expand students’ understanding of denitrative processes, stimulate their interest in the field, enhance their learning experience, and enrich their knowledge base.

Key words: Nitroarenes, Denitrative transformation, Electrosynthesis, Aryl boronates, Aryl sulfonyl fluorides