大学化学 >> 2025, Vol. 40 >> Issue (2): 255-261.doi: 10.12461/PKU.DXHX202405163

所属专题: 化学科普(2025)

科普 上一篇    下一篇

NO便携治疗探索之路

赵杨波1, 张煜彦1, 翟佳惠1, 毛宇佳1, 沈珍2, 陈建成2   

  1. 1 南京诺令生物科技有限公司, 南京 211800;
    2 南京大学化学化工学院, 南京 210023
  • 收稿日期:2024-05-27 录用日期:2024-08-12 发布日期:2024-12-19
  • 通讯作者: 毛宇佳, 陈建成 E-mail:yujia.mao@novlead.com;kschan@nju.edu.cn
  • 基金资助:
    南京大学百位名师邀约项目;南京大学国际化课程建设项目;南京大学短期国外专家项目

The Journey towards Portable NO Inhalation Therapy

Yangbo Zhao1, Yuyan Zhang1, Jiahui Zhai1, Yujia Mao1, Zhen Shen2, Kin Shing Chan2   

  1. 1 Nanjing Novlead Biotechnology Co., Ltd., Nanjing 211800, China;
    2 School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
  • Received:2024-05-27 Accepted:2024-08-12 Published:2024-12-19
  • Contact: Yujia Mao, Kin Shing Chan E-mail:yujia.mao@novlead.com;kschan@nju.edu.cn

摘要: 医院急救室里,NO奇迹般地把一个呼吸衰竭的孩子从死亡线上拉了回来。医护人员感慨NO的神奇功效之余,也不免因钢瓶的笨重、不安全而烦恼。不久后一次与化学家朋友的闲聊却给了医生意外之喜:NO原来可以即时发生和使用,而且由于N的化合物能以多种价态稳定存在,有许多制备NO的方案可供选择,便携式NO治疗仪指日可待!在研发团队的共同努力下,各种各样的方案不断被提出、评估、试验。经历了一遍遍修改完善,最终NO即时发生治疗仪被成功研发出来,代替钢瓶在医院被广泛应用。新的NO治疗仪由于便携易用得到了医生护士一致好评,研发团队也因此受邀分享他们研发和创业的经验与心得。如批判性思维、创造力、人员管理、与他人协调等,都是不可或缺的因素,是团队通往成功的基石。

关键词: 一氧化氮, 吸入治疗, 即时发生

Abstract: In an emergency room, nitric oxide (NO) miraculously saved a child from respiratory failure. While the medical staff were amazed by NO’s remarkable effects, they were equally frustrated by the bulkiness and safety concerns of the gas cylinders used to deliver it. However, a casual conversation with a chemist brought a surprising revelation: NO could be generated on demand, thanks to the stability of nitrogen compounds in various valence states, which allowed for multiple generation methods. This inspired the development of a portable NO therapy device. With the collective efforts of the R&D team, various solutions were proposed, evaluated, and tested. After numerous refinements, the portable NO generation device was successfully developed and is now widely used in hospitals, replacing traditional cylinders. Praised for its portability and ease of use, the device has been well-received by doctors and nurses. The R&D team was invited to share their insights into the development process and the importance of critical thinking, creativity, team management, and collaboration, all of which were key to their success.

Key words: Nitric oxide, Inhalation therapy, On-demand generation