大学化学 >> 2025, Vol. 40 >> Issue (7): 294-299.doi: 10.12461/PKU.DXHX202409092

化学实验 上一篇    下一篇

Minisci反应合成1-苄基异喹啉

廖慧娟, 肖玉林, 薛东, 杨明瑜, 董建洋   

  1. 陕西师范大学化学化工学院, 西安 710119
  • 收稿日期:2024-09-23 录用日期:2024-12-23 发布日期:2025-07-01
  • 通讯作者: 董建洋 E-mail:jydong@snnu.edu.cn
  • 基金资助:
    陕西省重点研发计划项目(2024SF2-GJHX32)；陕西师范大学化学专业有机化学实验教学模式改革实践研究项目(24JBGS27)

Synthesis of 1-Benzyl Isoquinoline via the Minisci Reaction

Huijuan Liao, Yulin Xiao, Dong Xue, Mingyu Yang, Jianyang Dong   

  1. School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China
  • Received:2024-09-23 Accepted:2024-12-23 Published:2025-07-01
  • Contact: Jianyang Dong E-mail:jydong@snnu.edu.cn

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摘要： 在酸性和氧化条件下，烷基自由基对氮杂芳环的加成反应即Minisci反应，是一种很高效地合成烷基取代的氮杂芳环的方法。我们使用苄基三甲基硅烷做烷基自由基前体，过硫酸盐做氧化剂，二甲基亚砜做反应溶剂，通过Minisci反应高效合成了1-苄基异喹啉。该实验是本校大三本科生的研究型实验，此实验可训练提高学生的科学研究和实验操作能力，激发学生的创新意识。

关键词: 苄基三甲基硅烷, 异喹啉, Minisci反应, 教学实验

Abstract: The Minisci reaction is an efficient method for synthesizing alkyl-substituted N-heteroarenes, involving the addition of alkyl radicals to N-heteroarenes under acidic and oxidative conditions. In this study, 1-benzyl isoquinoline was synthesized through the Minisci reaction using benzyl trimethylsilane as the alkyl radical precursor, ammonium persulfate ((NH₄)₂S₂O₈) as the oxidant, and dimethyl sulfoxide (DMSO) as the solvent. This experiment serves as a research-based laboratory exercise for junior undergraduates at our university, aiming to enhance students' scientific research and experimental operation skills, and stimulate innovative thinking.

Key words: Benzyl trimethylsilane, Isoquinoline, Minisci reaction, Teaching experiment