大学化学 >> 2026, Vol. 41 >> Issue (7): 266-273.doi: 10.12461/PKU.DXHX202505015

化学实验 上一篇    

吡咯并[1,2-a]喹喔啉类抗肿瘤活性剂的绿色合成——综合化学实验教学探究

盛荟茹1, 齐蕊1, 沈超1, 徐好1, 沈佳斌1, 章鹏飞2   

  1. 1 浙江树人学院生物与环境工程学院, 浙江省化学与生物基础实验教学示范中心, 浙江 杭州 310015;
    2 杭州师范大学材料与化学化工学院, 浙江省化学实验教学示范中心, 浙江 杭州 311121
  • 收稿日期:2025-05-08 录用日期:2025-07-29 发布日期:2026-06-27
  • 通讯作者: 沈佳斌, 章鹏飞 E-mail:shenjiabinhznu@163.com;pfzhang@hznu.edu.cn Jiabin Shen, Pengfei Zhang
  • 基金资助:
    浙江省自然科学基金(LQN25B060012);国家自然科学基金(22302178)

Green synthesis of pyrrolo[1,2-a]quinoxaline derivatives as antineoplastic agents: a comprehensive chemistry laboratory teaching exploration

Huiru Sheng1, Rui Qi1, Chao Shen1, Hao Xu1, Jiabin Shen1, Pengfei Zhang2   

  1. 1 Basic Chemistry and Biology Experiments Teaching Center of Zhejiang Province, College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, Zhejiang Province, China;
    2 Experimental Chemistry Teaching Center of Zhejiang Province, College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, China
  • Received:2025-05-08 Accepted:2025-07-29 Published:2026-06-27
  • Contact: Jiabin Shen, Pengfei Zhang E-mail:shenjiabinhznu@163.com;pfzhang@hznu.edu.cn

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摘要： 本实验选择具有抗肿瘤活性的吡咯并[1,2-a]喹喔啉类分子骨架为研究对象，以硝酸和盐酸为氯气前体，在可见光催化下，利用芳基环丙烷的开环和关环反应一步合成吡咯并[1,2-a]喹喔啉类抗肿瘤活性剂。本实验将有机化学基础知识和学科前沿热点相结合，有助于提升学生的综合素质和创新能力，适合作为化学专业高年级的“综合化学实验”课程。

关键词: 开环反应, 关环反应, 吡咯并[1,2-a]喹喔啉, 光催化, 均相催化

Abstract: This study focuses on the molecular framework of pyrrolo[1,2-a]quinoxaline, known for its antitumor activity. Utilizing nitric acid and hydrochloric acid as chlorine gas precursors, we achieved a one-step synthesis of pyrrolo[1,2-a]quinoxaline antitumor agents through visible-light-catalyzed ring-opening and ring-closing reactions of arylcyclopropanes. By integrating fundamental organic chemistry principles with cutting-edge research topics, this experiment effectively enhances students’ comprehensive skills and innovative capabilities, making it particularly suitable as an advanced “comprehensive chemistry experiment” course for chemistry majors.

Key words: Ring-opening reaction, Ring-closing reaction, Pyrrolo[1,2-a]quinoxaline, Photocatalysis, Homogeneous catalysis