大学化学 >> 2026, Vol. 41 >> Issue (7): 219-226.doi: 10.12461/PKU.DXHX202506067

科普 上一篇    

磁热特工队战记

李玉洁1, 刘佳玉1, 刘文博2, 张廷斌3, 沈康宇1, 罗佳1, 和媛1, 彭明丽1, 刘晓丽4, 樊海明1   

  1. 1 西北大学化学与材料科学学院, 陕西 西安 710127;
    2 西北大学文学院, 陕西 西安 710127;
    3 河北工业大学生命科学与健康工程学院, 天津 300131;
    4 西安交通大学精准外科与再生医学国家地方联合工程研究中心, 陕西 西安 710061
  • 收稿日期:2025-06-15 录用日期:2025-08-29 发布日期:2026-06-27
  • 通讯作者: 彭明丽, 刘晓丽, 樊海明 E-mail:mlpeng@nwu.edu.cn;fanhm@nwu.edu.cn;liuxiaoli0108@xjtu.edu.cn Mingli Peng, Xiaoli Liu, Haiming Fan
  • 基金资助:
    国家自然科学基金面上项目(82472108,22072115);国家自然科学基金优秀青年科学基金项目(82322039);陕西省自然科学基金重点研发项目(2024SF-YBXM-408);西北大学本科人才培养建设项目(XM05232381)

The magnetothermal strike team: chronicles of the cancer war

Yujie Li1, Jiayu Liu1, Wenbo Liu2, Tingbin Zhang3, Kangyu Shen1, Jia Luo1, Yuan He1, Mingli Peng1, Xiaoli Liu4, Haiming Fan1   

  1. 1 College of Chemistry and Materials Science, Northwest University, Xi'an 710127, Shaanxi Province, China;
    2 Faculty of Liberal Arts, Northwest University, Xi'an 710127, Shaanxi Province, China;
    3 School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300131, China;
    4 National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
  • Received:2025-06-15 Accepted:2025-08-29 Published:2026-06-27
  • Contact: Mingli Peng, Xiaoli Liu, Haiming Fan E-mail:mlpeng@nwu.edu.cn;fanhm@nwu.edu.cn;liuxiaoli0108@xjtu.edu.cn

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摘要： 在人类与癌症对抗中，近年来涡旋磁氧化铁纳米环以其卓越的磁热性能与灵活可调的表面功能化设计，联合铁死亡机制和免疫疗法等，成为实现多维立体抗癌策略的新一代“精兵”。本文以一场抗癌热战为切入点，介绍这种微小却强大的纳米环在交变磁场中展现出的超高比吸收率和表面功能化设计，不仅实现了对肿瘤细胞精准靶向识别，而且还能快速释放热能将其摧毁。通过这场热与免疫协同的战斗，希望向读者介绍磁性纳米材料在肿瘤磁热疗方面的知识，并激发大众对创新抗癌路径的探索热情。

关键词: 涡旋磁氧化铁纳米环, 癌症治疗, 磁热疗, 铁死亡, 免疫效应

Abstract: In humanity’s protracted battle against cancer, ferrimagnetic vortex iron oxide nanorings have recently emerged as a new generation of “precision troops” in anticancer strategies. These nanostructures combine exceptional magnetothermal properties with tunable surface functionalization, working synergistically with ferroptosis mechanisms and immunotherapy to enable multidimensional anticancer approaches. Using the metaphor of a thermal warfare campaign, this article elucidates how these diminutive yet potent nanorings demonstrate ultrahigh specific absorption rates under alternating magnetic fields while achieving precise tumor targeting through sophisticated surface design. Their capacity for rapid thermal energy release enables effective tumor destruction. Through this narrative of combined thermal and immunological warfare, we aim to introduce readers to magnetic nanomaterials in tumor hyperthermia applications and stimulate interest in innovative anticancer approaches.

Key words: Ferrimagnetic vortex iron oxide nanorings, Cancer therapy, Magnetic hyperthermia, Ferroptosis, Immunological effects