大学化学 >> 2026, Vol. 41 >> Issue (7): 154-160.doi: 10.12461/PKU.DXHX202504080

科普 上一篇    

悟空遇“妖”解迷津，液金施术救苍生

张梦莹1, 费代强2, 刘晓倩1, 孙小敏1, 白宇3, 王宇1, 吕查德1, 齐殿鹏1, 王磊1   

  1. 1 哈尔滨工业大学化工与化学学院, 黑龙江 哈尔滨 150001;
    2 哈尔滨工业大学数学学院, 黑龙江 哈尔滨 150001;
    3 黑龙江中医药大学, 黑龙江 哈尔滨 150040
  • 收稿日期:2025-04-28 录用日期:2025-08-29 发布日期:2026-06-27
  • 通讯作者: 吕查德, 齐殿鹏, 王磊 E-mail:leiwang_chem@hit.edu.cn;lv.chade@hit.edu.cn;dpqi@hit.edu.cn Chade Lv, Dianpeng Qi, Lei Wang
  • 基金资助:
    国家自然科学基金(52473109,52073071);黑龙江省自然科学基金优秀青年基金(YQ2022E021);黑龙江省龙江学者支持计划(王磊);黑龙江省高等教育教学改革研究项目(SJGYY2024002,SJGDB2024001)

The fabrication of liquid-metal-based micro/nano robots and their biomedical applications

Mengying Zhang1, Daiqiang Fei2, Xiaoqian Liu1, Xiaomin Sun1, Yu Bai3, Yu Wang1, Chade Lv1, Dianpeng Qi1, Lei Wang1   

  1. 1 School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, Heilongjiang Province, China;
    2 School of Mathematics, Harbin Institute of Technology, Harbin 150001, Heilongjiang Province, China;
    3 Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang Province, China
  • Received:2025-04-28 Accepted:2025-08-29 Published:2026-06-27
  • Contact: Chade Lv, Dianpeng Qi, Lei Wang E-mail:leiwang_chem@hit.edu.cn;lv.chade@hit.edu.cn;dpqi@hit.edu.cn

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摘要： 肿瘤疾病在人们日常生活中难以避免且难以治愈。而随着现代生物纳米技术的发展，科学家们设计出了一类智能微纳米材料——液态金属机器人。液态金属机器人是基于生物技术、材料科学、微纳米技术、机械学等多学科交叉的新兴研究领域。由于其体型微小，可以在外场的控制下发生各种各样的形变，使其能够靶向治疗癌细胞，但该技术还并未广为人知。本文基于四大名著之一——《西游记》，以拟人化的手法讲述了液态金属机器人的制备方法、变形特点及体内治疗过程，以期促进广大读者对液态金属机器人科学机理的了解，为实现该技术的实际应用奠定基础。

关键词: 液态金属, 微纳米机器人, 肿瘤治疗, 形变机理, 驱动方式

Abstract: Cancer remains a prevalent and challenging disease in modern society. With recent advancements in bionanotechnology, researchers have developed intelligent micro/nanomaterials known as liquid-metal-based robots. This emerging interdisciplinary technology combines biotechnology, materials science, nanoengineering, and mechanical systems. These miniature robots can undergo controlled morphological transformations under external fields, enabling targeted cancer therapy, though the technology remains relatively unknown. Drawing inspiration from the literary classic “Journey to the West”, this study employs anthropomorphic narrative techniques to elucidate the fabrication methods, deformation characteristics, and therapeutic processes of liquid-metal robots in vivo. This article aims to enhance public understanding of the scientific principles underlying these transformative biomedical agents, thereby facilitating their practical clinical applications.

Key words: Liquid metal, Micro/nanorobots, Tumor therapy, Deformation mechanism, Actuation methods