大学化学 >> 2024, Vol. 39 >> Issue (11): 342-349.doi: 10.12461/PKU.DXHX202404141

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近红外二区光学诊疗探针的制备及性能测试——高分子化学综合实验的新设计与教学实践

王其, 高逸聪, 陆峰, 范曲立   

  1. 南京邮电大学材料科学与工程学院, 南京 210023
  • 收稿日期:2024-04-23 录用日期:2024-07-04 发布日期:2024-11-09
  • 通讯作者: 王其 E-mail:iamqwang@njupt.edu.cn
  • 基金资助:
    南京邮电大学教学改革研究项目(JG03023JX103)；国家自然科学基金面上项目(22175098)

Preparation and Performance Characterization of the Second Near-Infrared Phototheranostic Probe: A New Design and Teaching Practice of Polymer Chemistry Comprehensive Experiment

Qi Wang, Yicong Gao, Feng Lu, Quli Fan   

  1. School of Materials Science and Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210023, China
  • Received:2024-04-23 Accepted:2024-07-04 Published:2024-11-09
  • Contact: Qi Wang E-mail:iamqwang@njupt.edu.cn

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摘要： 癌症已经成为当今威胁人类健康的重大疾病之一，发展新型光学诊疗体系用于癌症精准诊断与高效治疗至关重要。本文介绍了一个高分子化学综合实验的新设计与教学实践，即一种新型共轭高分子基近红外二区光学诊疗探针的制备过程及其相关性能测试。该实验包括共轭高分子合成、水溶性纳米粒子制备、吸收发射光谱测定、光热光动力性能分析、近红外二区荧光成像及对癌细胞光毒性研究。该实验内容科学性及前沿性强，能够提高学生的实验操作技能，引导学生运用所学知识进行独立思考，启发学生的创新及科研思维。

关键词: 癌症, 共轭高分子, 光学诊疗探针, 性能测试, 综合实验

Abstract: Cancer has become one of the most significant threats to humans, and the development of novel phototherapeutic agents for precise diagnosis and efficient treatment of cancer is crucial. This article introduces a new design and teaching practice of a polymer chemistry comprehensive experiment, which involves the preparation process and related performance testing of a novel conjugated polymer based second near-infrared phototheranostic probe. This experiment includes the synthesis of conjugated polymers, preparation of water-soluble nanoparticles, determination of absorption and emission spectra, analysis of photothermal and photodynamic properties as well as second near-infrared fluorescence imaging, and study of the phototoxicity to cancer cells. This experiment has strong scientific and cutting-edge content, which can improve students' experimental operation skills, guide them to apply their learned knowledge for independent thinking, and inspire students' innovation and scientific research thinking.

Key words: Cancer, Conjugated polymers, Phototheranostic probe, Performance testing, Comprehensive experiment