Matteson反应在有机合成中的应用：基础到前沿

doi:10.12461/PKU.DXHX202411023

大学化学 >> 2025, Vol. 40 >> Issue (10): 114-120.doi: 10.12461/PKU.DXHX202411023

Matteson反应在有机合成中的应用：基础到前沿

肖岩松, 黄熠, 马星星, 宋秋玲

福州大学化学学院, 福州 350108

收稿日期:2024-11-05 录用日期:2025-01-20 发布日期:2025-09-17
通讯作者: 马星星, 宋秋玲 E-mail:maxx@fzu.edu.cn;qsong@fzu.edu.cn
基金资助:
污染物分析与资源化技术湖北省重点实验室开放基金重点项目(PA240102);福建省自然科学基金(2022J02009)

The Matteson Reaction in Organic Synthesis: From Fundamentals to Frontiers

Yansong Xiao, Yi Huang, Xingxing Ma, Qiuling Song

College of Chemistry, Fuzhou University, Fuzhou 350108, China

Received:2024-11-05 Accepted:2025-01-20 Published:2025-09-17
Contact: Xingxing Ma, Qiuling Song E-mail:maxx@fzu.edu.cn;qsong@fzu.edu.cn

摘要/Abstract

摘要： Matteson反应近年来备受关注，是有机硼化合物合成的核心技术之一，且在复杂分子构建与药物开发等领域展现出巨大应用价值。本综述聚焦Matteson反应，先阐述了其反应原理与基本机理，为理解后续进展奠定基础。进而深入分析该反应在实际应用中的拓展，包括作为关键步骤助力复杂天然产物等的全合成以及用于生产药物关键中间体等。

关键词: 有机硼化合物, 合成中间体, Matteson反应, 增碳/同系化反应

Abstract: The Matteson reaction has garnered significant attention in recent years as one of the cornerstone methodologies for organoboron compound synthesis, demonstrating remarkable utility in complex molecule construction and pharmaceutical development. This comprehensive review systematically examines the Matteson reaction, beginning with an elucidation of its fundamental principles and mechanistic underpinnings to establish a conceptual framework. Subsequently, we provide a critical analysis of contemporary advancements in its practical applications, particularly highlighting its pivotal role as a key transformation in the total synthesis of complex natural products and the production of pharmaceutically relevant intermediates.

Key words: Organoboron compounds, Synthetic intermediates, Matteson reaction, Carbon-added/Homologation reaction

肖岩松, 黄熠, 马星星, 宋秋玲. Matteson反应在有机合成中的应用：基础到前沿[J]. 大学化学, 2025, 40(10): 114-120.

Yansong Xiao, Yi Huang, Xingxing Ma, Qiuling Song. The Matteson Reaction in Organic Synthesis: From Fundamentals to Frontiers[J]. University Chemistry, 2025, 40(10): 114-120.

链接本文: https://www.dxhx.pku.edu.cn/CN/10.12461/PKU.DXHX202411023

https://www.dxhx.pku.edu.cn/CN/Y2025/V40/I10/114

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Matteson反应在有机合成中的应用：基础到前沿

The Matteson Reaction in Organic Synthesis: From Fundamentals to Frontiers

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