大学化学 >> 2025, Vol. 40 >> Issue (10): 161-165.doi: 10.12461/PKU.DXHX202411027

所属专题： 化学科普(2025)

科普 上一篇    下一篇

“碱”入佳境——喜树碱变身之旅

沈子墨1, 张桐玮1, 朱芷怡1, 贡宗豪1, 冯清2, 杨金燚3, 李真3, 刘敏2, 齐伟2   

  1. 1 华中科技大学同济医学院护理学院, 武汉 430030;
    2 华中科技大学化学与化工学院, 武汉 430074;
    3 河南金数网科信息技术有限公司, 郑州 410100
  • 收稿日期:2024-11-06 录用日期:2025-02-24 发布日期:2025-09-17
  • 通讯作者: 刘敏, 齐伟 E-mail:liumin@hust.edu.cn;qiwei@hust.edu.cn
  • 基金资助:
    教育部产学合作协同育人项目(231003226085746);华中科技大学教学研究专项项目(2023019)

From Alkaloid to Anticancer Agent: The Transformative Journey of Camptothecin

Zimo Shen1, Tongwei Zhang1, Zhiyi Zhu1, Zonghao Gong1, Qing Feng2, Jinyi Yang3, Zhen Li3, Min Liu2, Wei Qi2   

  1. 1 School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;
    2 School of Chemical Engineering and Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China;
    3 Henan Jinshu Network Technology Co., Ltd., Zhengzhou 410100, China
  • Received:2024-11-06 Accepted:2025-02-24 Published:2025-09-17
  • Contact: Min Liu, Wei Qi E-mail:liumin@hust.edu.cn;qiwei@hust.edu.cn

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摘要： 源于中华本草的喜树碱是一种重要的抗癌物质，本文以科幻小说的形式构思了喜树碱大战肿瘤细胞的场景，通过科学且风趣的语言描述了其性质、作用机理，以及在结构修饰、功能提升、临床应用等方面的研究工作进展。

关键词: 喜树碱, 抗肿瘤, 结构修饰, 药物递送系统

Abstract: Camptothecin, a potent anticancer agent derived from traditional Chinese medicine, serves as the focal point of this article. Through the imaginative lens of a science fiction narrative, the article depicts camptothecin’s battle against tumor cells. Employing a combination of scientific rigor and engaging language, it elucidates the compound’s properties, mechanisms of action, and recent research progress in structural modifications, functional enhancements, and clinical applications.

Key words: Camptothecin, Antitumor, Structural modification, Drug delivery system