大学化学 >> 2026, Vol. 41 >> Issue (7): 250-256.doi: 10.12461/PKU.DXHX202504035

化学实验 上一篇    

微反应器中的酯化反应综合探究实验

高明丽1, 冯红艳1, 蒋晨啸2, 王梓豪2, 余维胜2   

  1. 1 化学国家级实验教学示范中心(中国科学技术大学), 安徽 合肥 230026;
    2 中国科学技术大学化学与材料科学学院应用化学系, 安徽 合肥 230026
  • 收稿日期:2025-04-08 录用日期:2025-06-20 发布日期:2026-06-27
  • 通讯作者: 冯红艳 E-mail:fenghy@ustc.edu.cn Hongyan Feng
  • 基金资助:
    校级重点教研项目(2023xjyxm004,2023xjyxm012);校级教研项目(2025xkcszkc04,2022xjyxm052)

A comprehensive exploratory experiment on esterification reaction in microreactors

Mingli Gao1, Hongyan Feng1, Chenxiao Jiang2, Zihao Wang2, Weisheng Yu2   

  1. 1 National Demonstration Center for Experimental Chemistry Education (University of Science and Technology of China), Hefei 230026, Anhui Province, China;
    2 Department of Applied Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, Anhui Province, China
  • Received:2025-04-08 Accepted:2025-06-20 Published:2026-06-27
  • Contact: Hongyan Feng E-mail:fenghy@ustc.edu.cn

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摘要： 介绍了一个运用新颖反应器的综合探究实验：在微反应器中，进行乙酸和乙醇的酯化反应。学生以小组形式，通过改变实验条件，如反应温度、原料比、停留时间、催化剂用量等，考察对原料转化率的影响，学习应用核磁共振氢谱推测反应发生的程度。通过该实验，学生了解了微反应器新实验技术，学习了利用核磁共振氢谱进行定量分析的方法，提高了分析思考能力。

关键词: 微反应器, 综合探究实验, 酯化反应, 核磁共振技术

Abstract: This study presents an innovative comprehensive experiment utilizing microreactor technology to investigate the esterification reaction between acetic acid and ethanol. Conducted in student groups, the experiment systematically examines the influence of various reaction parameters—including temperature, reactant molar ratio, residence time, and catalyst concentration—on conversion efficiency. Participants acquire skills in employing proton nuclear magnetic resonance (1H NMR) spectroscopy to monitor reaction progression and quantify conversion rates. The experimental design not only familiarizes students with advanced microreactor technology but also develops their proficiency in quantitative 1H NMR analysis, while simultaneously enhancing their analytical thinking capabilities.

Key words: Microreactor, Comprehensive exploratory experiment, Esterification reaction, Nuclear magnetic resonance technology