动态双配体接力策略促进钯催化不对称反应的研究进展

doi:10.12461/PKU.DXHX202604153

大学化学

动态双配体接力策略促进钯催化不对称反应的研究进展

罗洲¹, 陈宏超¹, 刘媛媛², 杨国强¹

1 上海交通大学化学化工学院, 变革性分子前沿科学中心, 上海 200240;
2 华东师范大学化学与分子工程学院, 上海 200062

收稿日期:2026-04-30 录用日期:2026-07-24
通讯作者: 杨国强, 刘媛媛 E-mail:gqyang@sjtu.edu.cn;yyliu@chem.ecnu.edu.cn Guoqiang Yang, Yuanyuan Liu
基金资助:
国家自然科学基金(22371073)；中央高校基本科研业务费专项资金资助(25X010202131)；聚烯烃催化技术与高性能材料全国重点实验室(SKLZX-2025-11)

Recent progress in dynamic dual-ligand relay-enabled Pd-catalyzed asymmetric reactions

Zhou Luo¹, Hongchao Chen¹, Yuanyuan Liu², Guoqiang Yang¹

1 Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;
2 School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China

Received:2026-04-30 Accepted:2026-07-24
Contact: Guoqiang Yang, Yuanyuan Liu E-mail:gqyang@sjtu.edu.cn;yyliu@chem.ecnu.edu.cn

摘要/Abstract

摘要： 手性分子在医药、农药等领域应用广泛，其高选择性合成是有机化学的核心研究方向。其中，金属催化的不对称反应是制备此类光学纯化合物的高效途径，但传统单一配体催化模式常面临配体合成复杂、反应选择性与收率难以兼顾等挑战。动态双配体接力催化通过两种配体在同一催化循环中的协同接力作用，可灵活调控反应活性与立体选择性，为金属催化不对称反应提供了新策略。本文系统梳理了该领域的发展历程，重点阐述动态双配体接力钯催化的作用机制及典型反应，结合前沿进展分析其应用价值，旨在帮助学生夯实金属有机基元反应理论基础，拓展学科前沿视野，完善有机化学知识体系。

关键词: 不对称催化, 钯催化, 双配体体系, 动态双配体接力, 配体交换

Abstract: Chiral molecules are widely utilized in pharmaceuticals, agrochemicals, and related fields, and thus their highly selective synthesis represents a central research focus in organic chemistry. Metal-catalyzed asymmetric reactions offer an efficient route to such enantiopure compounds; however, conventional singleligand catalytic systems often face challenges, including intricate ligand synthesis and a trade-off between reaction selectivity and yield. Dynamic dual-ligand relay catalysis, which leverages the synergistic relay of two distinct ligands within a single catalytic cycle, enables flexible modulation of both reactivity and stereoselectivity, thereby offering a novel strategy for metal-catalyzed asymmetric transformations. This review systematically outlines the development of this field, with an emphasis on the mechanistic underpinnings and representative reactions of palladium-catalyzed asymmetric processes enabled by dynamic dual-ligand relay. It also examines recent advances and application prospects, aiming to reinforce students’ understanding of fundamental organometallic elementary reactions, broaden their awareness of cutting-edge research, and enrich their overall knowledge framework of organic chemistry.

Key words: Asymmetric catalysis, Palladium catalysis, Dual-ligand system, Dynamic dual-ligand relay, Ligand exchange

罗洲, 陈宏超, 刘媛媛, 杨国强. 动态双配体接力策略促进钯催化不对称反应的研究进展[J]. 大学化学, 2026, (): 2604153.

Zhou Luo, Hongchao Chen, Yuanyuan Liu, Guoqiang Yang. Recent progress in dynamic dual-ligand relay-enabled Pd-catalyzed asymmetric reactions[J]. University Chemistry, 2026, (): 2604153.

链接本文: https://www.dxhx.pku.edu.cn/CN/10.12461/PKU.DXHX202604153

https://www.dxhx.pku.edu.cn/CN/Y2026/V/I/2604153

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