关键词: 沙芬酰胺, 微波合成, 还原胺化

Abstract: This study focuses on the design of a teaching experiment of synthesizing safinamide methanesulfonate, a drug for treating Alzheimer’s disease. Starting from 4-(3-fluorobenzyloxy)benzaldehyde, the microwave synthesis technique was employed in a reductive amination strategy to rapidly and efficiently obtain the target product through three consecutive reactions. The product’s structure and purity were confirmed through NMR, melting point, and specific rotation analysis. This experiment not only enhances students’ organic synthesis skills but also emphasizes the integration of knowledge across disciplines.

Key words: Safinamide methanesulfonate, Microwave-assisted synthesis, Reductive amination