大学化学 >> 2025, Vol. 40 >> Issue (4): 253-260.doi: 10.12461/PKU.DXHX202405171

所属专题: 自由基化学

知识介绍 上一篇    下一篇

有机自由基材料在生物医学中的应用

冯丽娜, 姜国玉, 菅晓霞, 王建国   

  1. 内蒙古大学化学化工学院, 呼和浩特 010070
  • 收稿日期:2024-05-27 录用日期:2024-08-06 发布日期:2025-04-25
  • 通讯作者: 王建国 E-mail:wangjg@iccas.ac.cn
  • 基金资助:
    国家自然科学基金(22165020, 22161034, 22371151)

Application of Organic Radical Materials in Biomedicine

Lina Feng, Guoyu Jiang, Xiaoxia Jian, Jianguo Wang   

  1. College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010070, China
  • Received:2024-05-27 Accepted:2024-08-06 Published:2025-04-25
  • Contact: Jianguo Wang E-mail:wangjg@iccas.ac.cn

摘要: 将科学前沿案例引入课堂教学,不仅有助于阐明基础研究的实际应用价值,同时也能激发学生的好奇心,培养他们对前沿知识的探索热情。自由基化学作为有机化学的重要组成部分,因其本身具有高反应活性、反应机理复杂、产物多样等特点,一直被认为是有机化学学习中的重点与难点。近年来,有机自由基凭借其独特的窄带隙结构特征,在生物医学诊疗领域取得了一系列突破性进展,并成为国内外研究的热点。然而,自由基作为一类含有未成对电子的特殊化学物种,通常表现出动力学和热力学的不稳定性,这在很大程度上限制了其实际应用。鉴于此,本文探讨了稳定有机自由基的结构类型与合成策略,并进一步阐述了自由基材料在生物医学精准诊断和光诱导治疗领域的潜在应用前景。通过将最新的自由基研究成果融入课堂教学,有助于增强学生对该领域的理解和掌握。

关键词: 有机自由基, 生物成像, 光触发治疗

Abstract: Incorporating cutting-edge scientific examples into classroom teaching not only clarifies the practical value of fundamental research but also sparks students’ curiosity and fosters their enthusiasm for exploring advanced topics. Radical chemistry, a critical area of organic chemistry, is known for its high reactivity, complex mechanisms, and diverse products, making it both a key and challenging topic in organic chemistry education. In recent years, organic radicals, with their unique narrow-bandgap structural properties, have garnered significant attention in biomedical research, resulting in breakthroughs in diagnostics and treatment. However, as chemical species with unpaired electrons, radicals often exhibit kinetic and thermodynamic instability, which constrains their broader practical use. This article discusses the structural types and synthesis strategies for stabilizing organic radicals and explores their potential applications in precision biomedical diagnostics and photo-triggered therapies. Integrating the latest research on radicals into classroom instruction enhances students’ comprehension and expertise in this field.

Key words: Organic radical, Bioimaging, Photo-triggered therapy