关键词: 电化学合成, N-酰基磺酰胺, 去芳香螺环化, 实验教学

Abstract: Spiro compounds are of great interest in drug design and organic synthesis due to their unique three-dimensional structures and biological activities. Traditional methods for synthesizing spiro compounds often involve the use of stoichiometric oxidants, which can be harsh and complicated. In this experiment, dearomative spirocyclization of N-acyl sulfonamides is achieved efficiently and in an environmentally friendly manner through electrochemical oxidation. During the experimental course, students will learn the fundamental principles of electrochemical synthesis, acquire operational skills, and gain an understanding of the synthetic mechanisms involved in electrochemical dearomative spirocyclization. By guiding students to explore the experimental mechanisms and integrating theoretical knowledge with practical application, this approach enhances their experimental skills and scientific inquiry abilities while fostering an appreciation for green chemistry and sustainable synthesis methods.

Key words: Electrochemical synthesis, N-Acyl sulfonamides, Dearomative spirocyclization, Experiment teaching