大学化学 >> 2024, Vol. 39 >> Issue (3): 218-230.doi: 10.3866/PKU.DXHX202308106

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官能团添加策略在有机合成中的应用

朱信宇, 庞美丽()   

  • 收稿日期:2023-08-30 录用日期:2023-10-25 发布日期:2023-11-20
  • 通讯作者: 庞美丽 E-mail:pangmeili@nankai.edu.cn
  • 作者简介:第一联系人:

    †南开大学化学学院伯苓班2021级本科生

Application of Functional Group Addition Strategy in Organic Synthesis

Xinyu Zhu, Meili Pang()   

  • Received:2023-08-30 Accepted:2023-10-25 Published:2023-11-20
  • Contact: Meili Pang E-mail:pangmeili@nankai.edu.cn

摘要:

本文总结了在基础有机课程学习中常出现的官能团添加策略,尤其创新性地提出了羰基导向的胺的官能团添加来解决不同类型的胺的合成,并以实际天然产物或药物合成举例,以期使学生对官能团添加有更系统和深入的认识,同时在基础课程学习和实际科研间架起一座桥梁。

关键词: 有机合成设计, 逆合成分析, 官能团添加

Abstract:

This paper summarizes the strategies of functional group addition that often appear in basic organic courses. We innovatively propose the carbonyl-oriented functional group addition of amine to synthesize different types of amines. We expect to enable students to have a more systematic and in-depth understanding of functional group addition and to build a bridge between basic course learning and practical scientific research.

Key words: Organic synthesis design, Retrosynthetic analysis, Functional group addition