悟空巧饰磷脂膜，囊泡大败癌细胞

doi:10.12461/PKU.DXHX202404113

大学化学 >> 2024, Vol. 39 >> Issue (11): 182-188.doi: 10.12461/PKU.DXHX202404113

所属专题：化学科普(2024)

悟空巧饰磷脂膜，囊泡大败癌细胞

刘书羽^1,2, 孙小敏¹, 宋勃翰¹, 曾高峰¹, 杜冰冰¹, 果崇申¹, 王琮², 王磊¹

1 哈尔滨工业大学化工与化学学院, 哈尔滨 150001;
2 哈尔滨工业大学电信学院, 哈尔滨 150001

收稿日期:2024-04-17 录用日期:2024-05-07 发布日期:2024-11-09
通讯作者: 王琮, 王磊 E-mail:kevinwang@hit.edu.cn;leiwang_chem@hit.edu.cn
基金资助:
国家自然科学基金(52473109,52073071)；黑龙江省自然科学基金优秀青年基金(YQ2022E021)；中央高校基本科研业务费专项资金资助(HIT.DZJJ.2023056)；黑龙江省高等教育教学改革项目(SJGY20210302)

Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications

Shuyu Liu^1,2, Xiaomin Sun¹, Bohan Song¹, Gaofeng Zeng¹, Bingbing Du¹, Chongshen Guo¹, Cong Wang², Lei Wang¹

1 School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China;
2 School of Electronics and Information Engineering, Harbin Institute of Technology, Harbin 150001, China

Received:2024-04-17 Accepted:2024-05-07 Published:2024-11-09
Contact: Cong Wang, Lei Wang E-mail:kevinwang@hit.edu.cn;leiwang_chem@hit.edu.cn

摘要/Abstract

摘要： “我们能人工合成一个细胞吗？Can a cell be artificially synthesized？”——这是2021年《科学》期刊新发布的世界最前沿的125个重大科学问题之一。科学家为了揭示“生命起源”的奥秘以及解决世界关注的重大基础科学问题，设计出人造细胞这类仿生材料。它们最明显的特点就是具有与生物细胞类似的结构与功能。因此，深入研究人造细胞，不仅有利于研究真实细胞的结构与功能机制，还有助于建立非生物物质与真实细胞之间的联系，从而搭建非生命系统与生命系统之间的桥梁，为生命起源等相关研究提供实验与理论依据。而磷脂囊泡作为目前应用最为广泛的人造细胞更是有着广阔的应用前景。为了使“磷脂囊泡”这类材料以及相关研究技术得到更广泛的认识，本文基于耳熟能详的四大名著之一——《西游记》，讲述了孙悟空凭借火眼金睛帮助磷脂囊泡战胜癌细胞的故事，介绍了磷脂囊泡的设计和制备、代表功能以及体内治疗案例，以期促进广大读者对该技术的理解，并激发更多该技术潜在的应用可能。

关键词: 人造细胞, 磷脂囊泡, 巨型囊泡, 癌细胞, 靶向治疗, 免疫治疗

Abstract: “Can a cell be artificially synthesized?” This question stands among the 125 major scientific inquiries highlighted by the journal Science in 2021. To unravel the mysteries of the origin of life and address the fundamental scientific challenges, scientists have developed artificial cells as biomimetic materials mimicking the structure and functions of biological cells. Delving into artificial cells not only aids in understanding cellular mechanisms but also bridges the gap between non-living and living systems, offering insights and foundations for research into the origin of life and related fields. Phospholipid vesicles, particularly widely applied as artificial cells, hold vast potential in biomedical applications. This article, inspired by the classic tale of “Journey to the West”, narrates how phospholipid vesicles, aided by the Monkey King’s keen vision, combat cancer cells. It details the design, preparation, functionalities, and therapeutic applications of phospholipid-vesicle-based artificial cells, aiming to enhance readers’ understanding and stimulate further exploration of this transformative technology.

Key words: Artificial cells, Phospholipid vesicles, Giant vesicles, Cancer cells, Targeted treatment, Immunotherapy

刘书羽, 孙小敏, 宋勃翰, 曾高峰, 杜冰冰, 果崇申, 王琮, 王磊. 悟空巧饰磷脂膜，囊泡大败癌细胞[J]. 大学化学, 2024, 39(11): 182-188.

Shuyu Liu, Xiaomin Sun, Bohan Song, Gaofeng Zeng, Bingbing Du, Chongshen Guo, Cong Wang, Lei Wang. Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications[J]. University Chemistry, 2024, 39(11): 182-188.

链接本文: https://www.dxhx.pku.edu.cn/CN/10.12461/PKU.DXHX202404113

https://www.dxhx.pku.edu.cn/CN/Y2024/V39/I11/182

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悟空巧饰磷脂膜，囊泡大败癌细胞

Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications

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