大学化学 >> 2025, Vol. 40 >> Issue (7): 321-327.doi: 10.12461/PKU.DXHX202409056

化学实验 上一篇    下一篇

基于产品质量控制的大学化学实验设计——以“富马酸亚铁合成工艺的优化”为例

马海凤, 田笑丛, 王凤彬, 奚忠华, 王庆   

  1. 化学国家级实验教学示范中心(南京大学), 南京 210023
  • 收稿日期:2024-09-10 录用日期:2024-10-28 发布日期:2025-07-01
  • 通讯作者: 王庆 E-mail:wangqing@nju.edu.cn
  • 基金资助:
    数字赋能 全面提升化学本科实验教学质量——基于大类培养的《化学实验基础》教学内容更新 Z20240202

Design of College Chemistry Experiment Based on Product Quality Control: Taking “Optimization of Ferrous Fumarate Synthesis Process” as an Example

Haifeng Ma, Xiaocong Tian, Fengbin Wang, Zhonghua Xi, QingWang   

  1. National Demonstration Center for Experimental Chemistry Education (Nanjing University), Nanjing 210023, China
  • Received:2024-09-10 Accepted:2024-10-28 Published:2025-07-01
  • Contact: QingWang E-mail:wangqing@nju.edu.cn

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摘要： 为适应新时代化学类人才培养需求，依托原料药物产品的开发思路，设计了富马酸亚铁合成工艺的优化实验。实验涉及化合物的制备、滴定分析、仪器表征等内容，以研究式实验的方式开展，全面地训练了学生的综合实验能力，调动了学生的积极性，获得了良好的实验教学改革效果。优化后的合成工艺简单、快捷，使得富马酸亚铁在各项指标上都达到了药典的要求，有效实现了产品质量控制的目标。

关键词: 富马酸亚铁, 工艺优化, 研究式实验, 实验教学改革, 质量控制

Abstract: To address the evolving demands for chemical talent development in the new era, we designed an optimization experiment for the synthesis process of ferrous fumarate, incorporating the development principles of raw pharmaceutical products. This comprehensive experiment encompassed compound preparation, titration analysis, and instrumental characterization, conducted through a research-oriented approach. The implementation of this experiment effectively enhanced students' comprehensive experimental skills, stimulated their learning motivation, and achieved remarkable outcomes in experimental teaching reform. The optimized synthesis process demonstrated simplicity and efficiency, enabling ferrous fumarate to meet all pharmacopoeia specifications, thereby successfully accomplishing the objective of product quality control.

Key words: Ferrous fumarate, Process optimization, Research experiment, Experimental teaching reform, Quality control