大学化学 >> 2026, Vol. 41 >> Issue (2): 273-278.doi: 10.12461/PKU.DXHX202502020

所属专题： 化学科普(2025)

科普 上一篇    下一篇

沙利度胺“除三害”

卫柏同, 朱荣秀, 徐政虎   

  1. 山东大学化学与化工学院, 济南 250100
  • 收稿日期:2025-02-08 录用日期:2025-03-13 发布日期:2025-12-27
  • 通讯作者: 朱荣秀, 徐政虎 E-mail:rxzhu@sdu.edu.cn;xuzh@sdu.edu.cn Rongxiu Zhu, Zhenghu Xu
  • 基金资助:
    山东省自然科学基金(ZR2023MB072)；山东大学教育教学改革研究项目(2023Y061, 2024Z07)

Thalidomide: Defeating the Three Evils

Baitong Wei, Rongxiu Zhu, Zhenghu Xu   

  1. School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
  • Received:2025-02-08 Accepted:2025-03-13 Published:2025-12-27
  • Contact: Rongxiu Zhu, Zhenghu Xu E-mail:rxzhu@sdu.edu.cn;xuzh@sdu.edu.cn

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摘要： 沙利度胺曾因其致畸性而“臭名昭著”，但如今已被广泛用于炎症、恶性肿瘤及自身免疫病等多种疾病的治疗。传统的化学教材通常侧重于介绍沙利度胺的结构及致畸性，这导致学生对沙利度胺后期的发展了解不足，且不利于激发他们深入学习与该药物相关的化学知识的兴趣。本文借鉴中国传统故事“周处除三害”，通过第一人称视角，全面介绍沙利度胺的历史、作用机制、合成方法及其在现代医学中的应用，以激发读者的探索兴趣，促进他们对这一药物的深入了解。

关键词: 沙利度胺, 反应停, 麻风结节性红斑, 多发性骨髓瘤

Abstract: Thalidomide, once infamous for its teratogenic effects, is now widely utilized in treating inflammation, malignant tumors, and various autoimmune diseases. Traditional chemistry textbooks often emphasize its structure and teratogenicity, resulting in limited awareness of its subsequent developments and failing to inspire students to delve deeper into the chemical aspects of this drug. Drawing inspiration from the traditional Chinese story “Zhou Chu Eliminates Three Evils”, this article adopts a first-person narrative to comprehensively explore the history, mechanisms of action, synthesis methods, and modern medical applications of thalidomide. By doing so, it aims to ignite readers’ curiosity and foster a deeper understanding of this multifaceted drug.

Key words: Thalidomide, Contergan, Erythema nodosum leprosum, Multiple myeloma