大学化学 >> 2026, Vol. 41 >> Issue (10): 118-126.doi: 10.12461/PKU.DXHX202510003

知识介绍 上一篇    

P(III)/P(V)催化循环在Wittig反应中的应用研究进展

林宏珅, 胡雨潇, 常文举, 沈杰   

  1. 福州大学化学学院, 福建 福州 350108
  • 收稿日期:2025-10-09 录用日期:2025-11-26 发布日期:2026-10-13
  • 通讯作者: 常文举, 沈杰 E-mail:wenjuchang@fzu.edu.cn;ShenJie@fzu.edu.cn Wenju Chang, Jie Shen
  • 基金资助:
    福建省自然科学基金(2023J01054, 2025J08021)；国家自然科学基金面上项目(22371048)

Research advances in P(III)/P(V) catalytic cycle applications for Wittig reactions

Hongshen Lin, Yuxiao Hu, Wenju Chang, Jie Shen   

  1. College of Chemistry, Fuzhou University, Fuzhou 350108, Fujian Province, China
  • Received:2025-10-09 Accepted:2025-11-26 Published:2026-10-13
  • Contact: Wenju Chang, Jie Shen E-mail:wenjuchang@fzu.edu.cn;ShenJie@fzu.edu.cn

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摘要： 传统Wittig反应需使用化学计量的膦试剂，并不可避免地产生等当量的膦氧化物副产物，难以符合绿色化学理念。近年来，研究人员致力于发展P(III)/P(V)循环催化策略，利用催化量膦试剂实现高效转化，显著提高原子经济性。本文综述了催化型Wittig反应及其机理，旨在加深学生对绿色化学与反应机制的理解，促进科研成果与教学实践的融合。

关键词: Wittig反应, P(III)/P(V)氧化还原催化, 有机膦化合物, 绿色化学, 原子经济性

Abstract: Conventional Wittig reactions necessitate stoichiometric phosphine reagents and inevitably generate equimolar phosphine oxide byproducts, thereby conflicting with green chemistry principles. Recent research has focused on developing P(III)/P(V) redox catalytic strategies that achieve efficient transformations using only catalytic quantities of phosphine reagents, substantially enhancing atom economy. This review systematically examines catalytic Wittig reactions and their underlying mechanisms, with dual objectives of deepening students’ comprehension of green chemistry principles and reaction mechanisms, while facilitating the integration of scientific research findings with pedagogical practices.

Key words: Wittig reaction, P(III)/P(V) redox catalysis, Organic phosphorus compounds, Green chemistry, Atom economy