大学化学 >> 2026, Vol. 41 >> Issue (10): 182-189.doi: 10.12461/PKU.DXHX202509101

科普 上一篇    

G蛋白偶联受体的生命叙事：从信号密码到健康卫士

王星宇1, 任习嘉1, 张钰璐2, 杨悦惟2, 易婧妍3, 李媛4, 郭凯3   

  1. 1 西南医科大学医学影像系, 四川 泸州 640000;
    2 西南医科大学临床医学院, 四川 泸州 646000;
    3 西南医科大学基础医学院, 四川 泸州 646000;
    4 昆明理工大学学报编辑部, 云南 昆明 650500
  • 收稿日期:2025-09-24 录用日期:2025-11-20 发布日期:2026-10-13
  • 通讯作者: 郭凯 E-mail:guokai@swmu.edu.cn Kai Guo
  • 基金资助:
    四川省科普培训项目(2024JDKP0126)

The life narrative of G protein coupled receptors: from signal codes to health guardians

Xingyu Wang1, Xijia Ren1, Yulu Zhang2, Yuewei Yang2, Jingyan Yi3, Yuan Li4, Kai Guo3   

  1. 1 Department of Medical Imaging, Southwest Medical University, Luzhou 640000, Sichuan Province, China;
    2 Clinical Medical College, Southwest Medical University, Luzhou 640000, Sichuan Province, China;
    3 School of Basic Medical Sciences, Southwest Medical University, Luzhou 640000, Sichuan Province, China;
    4 Editorial Department of Journal of Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China
  • Received:2025-09-24 Accepted:2025-11-20 Published:2026-10-13
  • Contact: Kai Guo E-mail:guokai@swmu.edu.cn

PDF

44

赞

摘要： 以第20届人体健康卫士先进集体评选陈述会作为拟人化叙事框架，以上届获奖团队代表(受体酪氨酸激酶团队)阿洛为主持人，本届候选团队代表(G蛋白偶联受体团队)阿吉为陈述者。通过阿洛和阿吉的对话，系统展开围绕G蛋白偶联受体的科普叙事。全文涵盖三大核心内容。机制解密：追溯G蛋白的发现历史和结构特征，详解G蛋白偶联受体与G蛋白的结合、解离，鸟苷三磷酸/鸟苷二磷酸交换，构象变化的动态信号调控机制；疾病攻坚：拟人化呈现了G蛋白偶联受体成员在糖尿病血糖调控、高血压血管舒张、哮喘炎症反应中的干预机制；感官探索：系统介绍了G蛋白偶联受体成员介导视觉、嗅觉、甜味、鲜味、苦味、痒觉的信号转导机制。文章通过拟人化叙事手法，全面介绍了与G蛋白偶联受体相关的生物化学、病理生理学知识，既严谨展现了基础前沿知识，又通过“人体健康卫士”的隐喻，传递了珍爱生命、护佑健康、无私奉献的价值观。

关键词: 人体健康卫士, G蛋白偶联受体, G蛋白, 糖尿病, 哮喘, 高血压, 感官系统

Abstract: This article takes the 20th Advanced Collective Selection Presentation of Human Health Defenders as the narrative framework, with Alo, the representative of the previous award-winning team (receptor tyrosine kinase team), as the moderator, and Aji, the representative of the current candidate team (G protein coupled receptor team), as the presenter. Through the dialogue between Alo and Aji, the system unfolds a popular science narrative around G protein coupled receptors. The full text covers three core contents. Mechanism decryption: tracing the discovery history and structural characteristics of G protein, elaborating on the dynamic signal regulation mechanisms of G protein coupled receptors binding and dissociation with G protein, guanosine triphosphate/guanosine diphosphate exchange, and conformational changes; Disease tackling: anthropomorphic presentation of the intervention mechanism of G protein coupled receptor members in the regulation of blood glucose in diabetes, vasodilation in hypertension, and inflammatory response in asthma; Sensory exploration: the system introduces the signal transduction mechanism of G protein coupled receptor members mediating visual, olfactory, sweet, umami, bitter, and itchy sensations. The article comprehensively introduces the biochemical and pathophysiological knowledge related to G protein coupled receptors through personification narrative techniques. It not only rigorously presents basic cutting-edge knowledge, but also conveys the values of cherishing life, protecting health, and selfless dedication through the metaphor of “human health guardians”.

Key words: Human Health Defender, G protein coupled receptor, G protein, Diabetes, Asthma, Hypertension, Sensory system