大学化学 >> 2024, Vol. 39 >> Issue (12): 265-272.doi: 10.12461/PKU.DXHX202404058

所属专题： 自由基化学

化学实验 上一篇    下一篇

电化学芳香亲核取代反应实验设计

贾敬佩, 仇友爱   

  1. 南开大学化学学院, 天津 300071
  • 收稿日期:2024-04-10 录用日期:2024-05-23 发布日期:2024-12-17
  • 通讯作者: 仇友爱 E-mail:qiuyouai@nankai.edu.cn
  • 基金资助:
    国家重点研发计划项目(2022YFA1503200);国家自然科学基金项目(22371149,22188101);中央高校基本科研业务费专项资金项目(63223015);南开大学有机新物质创造前沿科学中心(63181206)

Experimental Design for the Electrochemical Nucleophilic Aromatic Substitution Reaction

Jingpei Jia, Youai Qiu   

  1. College of Chemistry, Nankai University, Tianjin 300071, China
  • Received:2024-04-10 Accepted:2024-05-23 Published:2024-12-17
  • Contact: Youai Qiu E-mail:qiuyouai@nankai.edu.cn

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摘要： 电化学有机合成是有机化学研究的重要前沿，但在本科实验教学中尚未得到推广。本实验依据最近的研究成果，设计了电化学条件下苯甲酸和4-氟苯甲醚的芳香亲核取代反应。实验包括产物制备、柱层析纯化、结构表征与循环伏安曲线测定四部分，旨在提高学生综合实验能力，并引导学生了解有机化学前沿成果，理解绿色化学发展理念。

关键词: 电化学合成, 自由基化学, 芳香亲核取代反应

Abstract: Electrochemical organic synthesis represents a crucial frontier in organic chemistry research, offering mild conditions and environmental friendliness. However, it has yet to be widely adopted in undergraduate laboratory teaching. This experiment is designed based on recent research findings to facilitate the nucleophilic aromatic substitution reaction of benzoic acid and 4-fluoroanisole under electrochemical conditions. The experiment includes four main components: product preparation, purification via column chromatography, structural characterization, and cyclic voltammetry (CV) analysis. The objective is to enhance students’ comprehensive experimental skills, introduce them to advanced organic chemistry topics, and instill an understanding of green chemistry principles.

Key words: Electrochemical synthesis, Radical chemistry, Nucleophilic aromatic substitution