大学化学 >> 2026, Vol. 41 >> Issue (1): 354-362.doi: 10.12461/PKU.DXHX202506001

所属专题： 化学实验数字化设计竞赛获奖作品

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纳米COF材料调节细胞内Ca2+浓度增强光动力治疗数字化实验

李维, 许寒, 谷传灿, 刘紫妍, 李延安, 耿琰   

  1. 山东师范大学化学化工与材料科学学院, 化学国家级实验教学示范中心(山东师范大学), 济南 250014
  • 收稿日期:2025-06-03 录用日期:2025-09-09 发布日期:2025-12-30
  • 通讯作者: 耿琰 E-mail:gengyan@sdnu.edu.cn Yan Geng
  • 基金资助:
    化学专业实验课程体系的优化和建构(SYJG050103)；三全育人机制下专创融合的化学卓越教师培养体系的构建(2024ZJ33)

Digital Experiment on Nano-COF Materials Modulating Intracellular Ca2+ Concentration to Enhance Photodynamic Therapy

Wei Li, Han Xu, Chuancan Gu, Ziyan Liu, Yan'an Li, Yan Geng   

  1. National Demonstration Center for Experimental Chemistry Education (Shandong Normal University), College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China
  • Received:2025-06-03 Accepted:2025-09-09 Published:2025-12-30
  • Contact: Yan Geng E-mail:gengyan@sdnu.edu.cn

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摘要： 本实验将前沿文献报道的纳米COF材料调节细胞内Ca2+浓度增强光动力治疗设计成一个扩展性强、多层次的综合化学实验引入本科教学。设计并开发了一套数字化虚拟仿真实验教学平台，并将其作为本科生综合化学实验开展。该平台建立了关于实验对象的数学物理和数据库模型，利用计算机数字化技术对实验场景进行虚拟仿真，实现了实验过程的高精度还原和实验结果的可视化呈现。与原实验相比，数字化实验通过模块化设计支持学生自主探索实验变量对结果的影响，强化其对专业知识的深度理解，同时规避了时长过长、成本较高和安全风险等缺点。教学过程始终践行“以学生为中心”的OBE理念。教学实践表明，该实验有助于提升学生的仪器操作规范性和数据分析处理能力，有效调动学生的学习积极性和创造力，对优化实验资源配置，深化实验教学改革提供了新思路。

关键词: COF, 数字化实验, 纳米材料

Abstract: This study introduces an advanced research protocol from current literature—employing nano covalent organic framework (COF) materials to regulate intracellular Ca²⁺ concentration for enhanced photodynamic therapy (PDT)—as a scalable, multi-level comprehensive chemistry experiment for undergraduate education. We developed a digital virtual simulation platform for experimental teaching and implemented it in undergraduate chemistry curricula. The platform incorporates mathematical, physical, and database models of the experimental system, utilizing digital technology to virtually simulate experimental conditions, thereby achieving high-fidelity replication of experimental procedures and visual presentation of results. Compared with traditional laboratory experiments, the digital platform features modular design that enables students to independently investigate the effects of experimental variables, deepening their subject knowledge while avoiding limitations such as excessive time requirements, high costs, and safety concerns. The teaching process consistently adheres to the student-centered Outcome-Based Education (OBE) approach. Teaching practice demonstrates that this experiment improves students’ instrumental operation skills, data analysis capabilities, and critical thinking, while effectively stimulating learning motivation and creativity. This approach offers new perspectives for optimizing experimental resource allocation and advancing chemistry laboratory education reform.

Key words: Covalent organic framework (COF), Digital experiment, Nanomaterials