大学化学 >> 2025, Vol. 40 >> Issue (11): 9998-9999.doi: 10.12461/PKU.DXHX202506061

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光诱导电子转移型Al3+荧光探针的设计合成——一个面向本科生教学的综合化学实验

马萧雄, 吴陈书, 张宏芳, 张健健   

  1. 西北大学化学与材料科学学院, 陕西 西安 710127
  • 收稿日期:2025-06-13 录用日期:2025-07-07 发布日期:2026-01-06
  • 通讯作者: 张健健 E-mail:zhangjj@nwu.edu.cn ZHANG Jianjian

Design and Synthesis of Photoinduced Electron Transfer-Type Al3+ Fluorescent Probe: A Comprehensive Chemistry Experiment for Undergraduate Teaching

Xiaoxiong Ma, Chenshu Wu, Hongfang Zhang, Jianjian Zhang   

  1. College of Chemistry and Materials Science, Northwest University, Xi'an 710127, Shanxi Province, China
  • Received:2025-06-13 Accepted:2025-07-07 Published:2026-01-06
  • Contact: ZHANG Jianjian E-mail:zhangjj@nwu.edu.cn

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摘要： 本文整合有机与分析化学构建Al3+荧光检测教学实验：基于光诱导电子转移(PET)机制设计腙类探针(Pro-MZ)。Pro-MZ在pH = 7.4下与Al3+特异性结合，荧光增强30倍，检出限为38.0 nmol∙L-1 (3σ/S)，且具有优异的选择性。结合实际样本检测回收率为98.7%–103.2%，10学时跨学科实验涵盖分子合成、光谱分析及应用验证，强化学生科研创新能力，为荧光探针教学提供创新方案。

关键词: 荧光探针, 铝离子检测, PET机制, 化学综合实验, 教学创新

Abstract: This study integrates organic and analytical chemistry to develop a fluorescence detection experiment for Al3+, featuring a hydrazone-based probe (Pro-MZ) designed through a photo-induced electron transfer (PET) mechanism. Pro-MZ specifically binds Al3+ at pH 7.4, achieving a 30-fold fluorescence enhancement at 471 nm with a detection limit of 38.0 nmol∙L-1 (3σ/S) and superior selectivity. Practical sample detection demonstrated recoveries of 98.7%–103.2%. The 10-period interdisciplinary curriculum combines molecular synthesis, spectral analysis, and real-world application validation, enhancing students’ research and innovative capabilities while establishing a novel pedagogical framework for fluorescence probe education.

Key words: Fluorescent probe, Al3+ detection, PET mechanism, Comprehensive chemistry experiment, Pedagogical innovation