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创新实验设计：脂肪醇聚氧乙烯醚磺酸钠的合成及性能评价

朱荣娇1,2, 李荣金1,2, 张振1,2, 邱丽娟1,2   

  1. 1 天津大学理学院化学系, 天津 300354;
    2 化学化工国家级实验教学示范中心(天津大学), 天津 300354
  • 收稿日期:2025-11-30 录用日期:2025-12-30
  • 通讯作者: 朱荣娇 E-mail:zhurongjiao@tju.edu.cn Rongjiao Zhu
  • 基金资助:
    天津市普通高等学校本科教学质量与教学改革研究计划项目(B251005611)；天津大学智慧教室应用场景典型案例建设； AI时代背景下物理化学课程思政的实施路径构建与实践研究

Innovative experiment design: synthesis and performance evaluation of sodium fatty alcohol polyoxyethylene ether sulfonate

Rongjiao Zhu1,2, Rongjin Li1,2, Zhen Zhang1,2, Lijuan Qiu1,2   

  1. 1 Department of Chemistry, School of Science, Tianjin University, Tianjin 300354, China;
    2 National Demonstration Center for Experimental Chemistry and Chemical Engineering Education, Tianjin University, Tianjin 300354, China
  • Received:2025-11-30 Accepted:2025-12-30
  • Contact: Rongjiao Zhu E-mail:zhurongjiao@tju.edu.cn

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摘要： 针对传统大学化学实验教学中存在的验证性实验占比高、科研与教学脱节、学生创新能力培养不足等问题，以油田驱油用关键表面活性剂——脂肪醇聚氧乙烯醚磺酸钠(AESO-3)的合成及性能评价为核心，设计了一套融合科研前沿、绿色化学理念与现代仪器应用的创新综合实验。实验以脂肪醇聚氧乙烯醚(AEO-3)和2-氯乙基磺酸钠为原料，通过单因素实验与响应面法优化合成工艺，结合红外光谱表征、表面张力测定、耐温耐盐及乳化性能测试等环节，构建了“合成-表征-优化-性能评价”的完整科研训练体系。教学实践表明，该实验不仅巩固了学生有机合成、仪器分析等基础理论知识，更培养了其实验设计、数据处理、问题解决及科研创新能力。实验符合安全环保要求，操作流程规范，可行性强，易于在高校化学及相关专业推广，为大学化学实验教学改革提供了新的思路与实践案例。

关键词: 脂肪醇聚氧乙烯醚磺酸钠, 创新实验设计, 响应面法, 表面活性剂, 科研能力培养

Abstract: To address the limitations in traditional university chemistry laboratory education—including the predominance of confirmatory experiments, the disconnect between research and teaching, and inadequate cultivation of students’ innovative capacities—we developed an innovative comprehensive experiment that incorporates cutting-edge research, green chemistry principles, and modern instrumentation. The experiment focuses on the synthesis and performance evaluation of sodium fatty alcohol polyoxyethylene ether sulfonate (AESO-3), a crucial surfactant for oilfield enhanced oil recovery. Using fatty alcohol polyoxyethylene ether (AEO-3) and sodium 2-chloroethyl sulfonate as starting materials, we optimized the synthesis process through single-factor experiments and response surface methodology. The experimental framework integrates infrared spectroscopy characterization, surface tension measurements, temperature/salt resistance tests, and emulsification performance evaluation, establishing a complete research training system encompassing “synthesis-characterization-optimization-performance evaluation”. Teaching practice demonstrates that this experiment not only reinforces students’ fundamental knowledge in organic synthesis and instrumental analysis but also enhances their capabilities in experimental design, data processing, problem-solving, and research innovation. The experiment meets all safety and environmental requirements, features standardized protocols, demonstrates high feasibility, and can be readily implemented in chemistry and related disciplines. This work provides both conceptual and practical contributions to the reform of university chemistry laboratory education.

Key words: Sodium fatty alcohol polyoxyethylene ether sulfonate, Innovative experiment design, Response surface methodology, Surfactant, Cultivation of scientific research ability