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32P入职记——从传统滤纸到3D打印水凝胶的核医学敷贴精准治疗技术演进

章艾萱2, 张子妍1, 刘佳文1, 张杨杨1, 李沐聪1, 周楚涵1, 张志豪1,3, 张涛1   

  1. 1 南京医科大学药学院, 江苏 南京 211166;
    2 南京医科大学第二临床医学院, 江苏 南京 211166;
    3 中国科学院生物物理研究所生物大分子全国重点实验室, 北京 100101
  • 收稿日期:2026-05-20 录用日期:2026-07-13
  • 通讯作者: 张志豪, 张涛 E-mail:zhangzhihaochem@163.com;zhangtaocjh@njmu.edu.cn Zhihao Zhang, Tao Zhang
  • 基金资助:
    国家自然科学基金(12275135, 12305390)；江苏省高校自然科学研究项目(24KJB350004)；2025年江苏省高等教育教改研究课题(2025JGYB501)

The onboarding adventures of 32P: evolution of precision therapy techniques in nuclear medicine applicators from traditional filter paper to 3D-printed hydrogels

Aixuan Zhang2, Ziyan Zhang1, Jiawen Liu1, Yangyang Zhang1, Mucong Li1, Chuhan Zhou1, Zhihao Zhang1,3, Tao Zhang1   

  1. 1 School of Pharmacy, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China;
    2 The Second Clinical Medical College, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China;
    3 State Key Laboratory of Biomacromolecules, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China
  • Received:2026-05-20 Accepted:2026-07-13
  • Contact: Zhihao Zhang, Tao Zhang E-mail:zhangzhihaochem@163.com;zhangtaocjh@njmu.edu.cn

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摘要： 以放射性核素32P的第一人称视角，通过拟人化的叙事方式，系统介绍了滤纸和水凝胶两种不同载体体系的核素敷贴。3D打印技术在水凝胶制备中的应用显著提升了材料的适形性，为精准医疗提供了有力支持。本文旨在以兼具科学性与趣味性的方式，帮助读者深入了解核素敷贴的工作原理和结构组成。

关键词: 32P, 核素敷贴, 水凝胶, 光交联, 3D打印, 瘢痕疙瘩, 科普

Abstract: From the first-person perspective of the radionuclide 32P, this paper systematically introduces radionuclide applicators based on two distinct carrier systems, filter paper and hydrogel, through an anthropomorphic narrative. The application of 3D printing technology in hydrogel fabrication significantly enhances conformability, providing strong support for precision medicine. This paper aims to help readers gain an in-depth understanding of the working principles and structural composition of radionuclide applicators in a manner that is both scientifically rigorous and engaging.

Key words: 32P, Radionuclide applicator, Hydrogel, Photocrosslinking, 3D printing, Keloid, Popularization of science