大学化学 >> 2016, Vol. 31 >> Issue (3): 64-67.doi: 10.3866/PKU.DXHX20160364

化学实验 上一篇    下一篇

苯佐卡因的改进合成——推荐一个环保的多步合成实验

刘金*(),韦琨,蔡乐,曹秋娥,刘世熙   

  • 发布日期:2016-04-06
  • 通讯作者: 刘金 E-mail:liujin@yun.edu.cn
  • 基金资助:
    云南省质量工程教改项目(X311308)

Improved Synthesis of Benzocaine: A Proposal for an Environmentally Friendly Oxidation Method as the Key Step

Jin LIU*(),Kun WEI,Le CAI,Qiu-E CAO,Shi-Xi LIU   

  • Published:2016-04-06
  • Contact: Jin LIU E-mail:liujin@yun.edu.cn
  • Supported by:
    云南省质量工程教改项目(X311308)

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摘要：

使用三氯异氰尿酸和2, 2, 6, 6-四甲基哌啶-1-氧化物(TEMPO)共氧化体系替代经典的铬酸氧化体系完成苯佐卡因的合成,避免了铬酸氧化体系毒性大、污染大、后处理困难等不利于环保的因素。共氧化体系安全、环保,具有反应产率高、反应时间短、反应条件温和、实验现象明显和易操作等特点。

关键词: 绿色化学, 苯佐卡因, 氧化, 三氯异氰尿酸, TEMPO

Abstract:

An improved synthesis of benzocaine is described. The synthetic route developed involves trichloroisocyanuric acid and 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO) co-oxidation system as the key step. The method could avoid high toxicity, pollution, post-processing difficulties and other unfavorable environmental factors. The reactions were carried out under room temperature for short time with high yield and safe, easy, and environment-friendly operation.

Key words: Green chemistry, Benzocaine, Oxidation, Trichloroisocyanuric acid, TEMPO