大学化学 >> 2025, Vol. 40 >> Issue (4): 326-330.doi: 10.12461/PKU.DXHX202406038

所属专题： 化学科普(2025)

科普 上一篇    下一篇

华法林：从毒药到良方

方洲1, 张致豪1, 蒋炜涵1, 陈建成2   

  1. 1 南京大学新生学院安邦书院, 南京 210023;
    2 南京大学化学化工学院, 南京 210023
  • 收稿日期:2024-06-11 录用日期:2024-08-12 发布日期:2025-04-25
  • 通讯作者: 陈建成 E-mail:kschan@nju.edu.cn
  • 基金资助:
    南京大学百位名师邀约项目；南京大学国际化课程建设项目；南京大学聘请短期国外专家项目

Warfarin: From Poison to Cure, the Remarkable Journey of a Molecule

Zhou Fang1, Zhihao Zhang1, Weihan Jiang1, Kin Shing Chan2   

  1. 1 Anbang Academy, College of First-Year Students, Nanjing University, Nanjing 210023, China;
    2 School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
  • Received:2024-06-11 Accepted:2024-08-12 Published:2025-04-25
  • Contact: Kin Shing Chan E-mail:kschan@nju.edu.cn

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摘要： 源起于发霉甜苜蓿，脱胎于生化实验室，华法林先生起初作为一种强力灭鼠毒药大杀四方。然而，在进入医药领域的道路上，他却因毒药的身份标签和种种流言而饱受质疑和反对。科学家们揭示了华法林抗凝血的机制，并证明了华法林抗凝治疗对患者的益处。从此，华法林先生以及他的衍生物们成为了抗凝治疗和防治鼠害的前线战士。

关键词: 抗凝药物, 双香豆素, 维生素K, 维生素K环氧化物还原酶

Abstract: Originating from moldy sweet clover and developed in a biochemical laboratory, warfarin was initially deployed as a potent rodenticide. However, its journey into the medical field was met with skepticism and opposition, largely due to its reputation as a poison and circulating rumors. Scientists eventually uncovered warfarin’s anticoagulant mechanism and demonstrated the benefits of its use in anticoagulation therapy for patients. Since then, warfarin and its derivatives have become key agents in both anticoagulant treatment and rodent control.

Key words: Anticoagulant, Dicoumarol, Vitamin K, Vitamin K epoxide reductase