大学化学 >> 2024, Vol. 39 >> Issue (8): 276-281.doi: 10.3866/PKU.DXHX202401005

化学实验 上一篇    下一篇

基于新医科理念的“氧化还原反应和电极电位”实验改进

周桐1, 李军1, 温紫甜1, 陈奕天1, 李海玲2, 高中洪2, 王文云2, 刘芳2, 冯清2, 李真3, 杨金燚3, 刘敏2, 齐伟2   

  1. 1. 华中科技大学同济医学院基础医学院, 武汉 430030;
    2. 华中科技大学化学与化工学院, 武汉 430074;
    3. 河南金数网科信息技术有限公司, 郑州 410100
  • 收稿日期:2024-01-02 修回日期:2024-02-26 发布日期:2024-04-02
  • 通讯作者: 刘敏, 齐伟 E-mail:liuming@hust.edu.cn;qiwei@hust.edu.cn
  • 基金资助:
    湖北省高等学校省级教学研究项目(2018050,2023040)；华中科技大学教学研究专项项目(2023019)

Experiment Improvement of “Redox Reaction and Electrode Potential” Based on the New Medical Concept

Tong Zhou1, Jun Li1, Zitian Wen1, Yitian Chen1, Hailing Li2, Zhonghong Gao2, Wenyun Wang2, Fang Liu2, Qing Feng2, Zhen Li3, Jinyi Yang3, Min Liu2, Wei Qi2   

  1. 1. School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;
    2. School of Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China;
    3. Henan Jinshu Network Technology Co., Ltd., Zhengzhou 410100, China
  • Received:2024-01-02 Revised:2024-02-26 Published:2024-04-02
  • Contact: Min Liu, Wei Qi E-mail:liuming@hust.edu.cn;qiwei@hust.edu.cn

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摘要： “新医科”是一种从治疗为主到兼具预防、治疗、康养的生命健康全周期的医学新理念。本文依据“新医科”理念，针对《医学基础化学实验》教材中的“氧化还原反应和电极电位”部分实验进行了“医学-化学-生物”等学科的交叉、融合与创新，具体有：(1) 电池电动势的测量实验中用乙二胺四乙酸钠(Na4Y)代替浓氨水，实现样品体系中Cu2+/Zn2+浓度的变化；(2) 氧化还原反应与电极电位的关系实验中用维生素C (Vc)的C6H6O6 (氧化型)/C6H8O6 (还原型)电对替代Br2/Br−电对，实现不同电对氧化还原性质的对比研究；(3) 增设谷胱甘肽还原Fe3+的实验，实现医学热点—细胞铁死亡过程的跨界思考。通过系列改进使实验变得绿色环保和医教结合，对诠释基础化学中的“新医科”理念具有重要意义。

关键词: 新医科, 氧化还原反应, 实验改进

Abstract: The concept of “New Medical Science” represents a paradigm shift in medicine, extending its focus from a primarily treatment-oriented practices to a comprehensive lifecycle that includes prevention, treatment, and wellness. Guided by the principle of “New Medical Science”, this paper conducts interdisciplinary innovation in the “Redox Reaction and Electrode Potential” experiment, a core component of the Basic Medical Chemistry Experiment curriculum. The innovation include: (1) Replacing concentrated ammonia with sodium ethylenediaminetetraacetate (Na4Y), a chelating agent commonly used in clinical settings, to alter the concentration of Cu2+/Zn2+ in the experiment measuring battery electromotive force; (2) Substituting the Br2/Br− redox couple with the C6H6O6 (oxidized form)/C6H8O6 (reduced form) redox couple of vitamin C (Vc) to study the redox properties of different redox couples;(3) Introducing an experiment that involves the reduction of Fe3+ by glutathione, fostering interdisciplinary thinking on the medically relevant process of cellular iron death. These modifications not only make the “Redox Reaction and Electrode Potential” experiment more eco-friendly but also bridge medical education and chemistry, underlining the importance of “New Medical Science” concept in foundational chemistry education.

Key words: New medical science, Oxidation-reduction reaction, Experimental improvement