大学化学 >> 2021, Vol. 36 >> Issue (6): 2008082.doi: 10.3866/PKU.DXHX202008082

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[1, 2]-Phospha-Brook重排反应研究进展

张茜苑1, 李玉明1, 苗志伟1,2,*()   

  1. 1 南开大学化学学院, 元素有机化学国家重点实验室, 天津 300071
    2 中低品位磷矿及其共伴生资源高效利用国家重点实验室, 贵州 550016
  • 收稿日期:2020-08-31 录用日期:2020-10-09 发布日期:2020-11-23
  • 通讯作者: 苗志伟 E-mail:miaozhiwei@nankai.edu.cn
  • 作者简介:苗志伟, Email: miaozhiwei@nankai.edu.cn
  • 基金资助:
    天津市科技支撑重点项目(19YFZCSN00240);中低品位磷矿及其共伴生资源高效利用国家重点实验室开放基金课题(WFKF2020-06);南开大学沧州渤海新区绿色化工研究院基金项目(NCC2020FC01)

Research Progress in[1, 2]-Phospha-Brook Rearrangement Reaction

Xiyuan Zhang1, Yuming Li1, Zhiwei Miao1,2,*()   

  1. 1 State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
    2 State Key Laboratory of Efficient Utilization of Low- and Medium-grade Phosphate Ore and Its Associated Resources, Guizhou 550016, China
  • Received:2020-08-31 Accepted:2020-10-09 Published:2020-11-23
  • Contact: Zhiwei Miao E-mail:miaozhiwei@nankai.edu.cn

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摘要：

[1, 2]-Phospha-Brook重排反应是重要的有机人名反应，在有机合成化学和药物化学等研究领域得到广泛应用。本文综述了近年来[1, 2]-Phospha-Brook重排反应在合成α-磷酰氧基酯和不同三元、五元和六元环状功能化合物中的研究进展，并对[1, 2]-Phospha-Brook重排反应未来发展方向进行展望。

关键词: [1, 2]-Phospha-Brook重排反应, 不对称合成, 研究进展

Abstract:

[1, 2]-Phospha-Brook rearrangement is an important organic name reaction that is widely used in several research fields such as organic synthetic chemistry and medicinal chemistry. This article reviews the recent progress of the[1, 2]-Phospha-Brook rearrangement reaction, with regard to its use in the synthesis of α-phosphoryloxy esters and different ternary, five- and six-membered cyclic functional compounds. We also provide insights into the future development direction of the[1, 2]-Phospha-Brook rearrangement reaction.

Key words: [1, 2]-Phospha-Brook rearrangement reaction, Asymmetric synthesis, Research progress