大学化学 >> 2023, Vol. 38 >> Issue (9): 141-147.doi: 10.3866/PKU.DXHX202210005

化学实验 上一篇    下一篇

综合化学实验：Fascaplysin类生物碱的命名、合成及表征

卢爱党(), 王瑞虎, 刘运亭, 姜艳军()   

  • 收稿日期:2022-10-04 录用日期:2022-12-09 发布日期:2023-09-21
  • 通讯作者: 卢爱党,姜艳军 E-mail:luaidang@hebut.edu.cn;yanjunjiang@hebut.edu.cn
  • 基金资助:
    河北省高等教育教学改革研究与实践项目(2021GJJG034);河北省研究生课程思政建设项目(YKCSZ2022015);河北省重点研发计划(21326504D);河北工业大学本科教育教学改革研究与实践项目

Comprehensive Chemistry Experiment: Nomenclature, Synthesis, and Characterization of Fascaplysin Alkaloids

Aidang Lu(), Ruihu Wang, Yunting Liu, Yanjun Jiang()   

  • Received:2022-10-04 Accepted:2022-12-09 Published:2023-09-21
  • Contact: Aidang Lu, Yanjun Jiang E-mail:luaidang@hebut.edu.cn;yanjunjiang@hebut.edu.cn

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摘要：

介绍了一个综合化学实验——Fascaplysin类生物碱的命名、合成及表征。实验内容涉及并环有机化合物的命名、合成、分离与纯化及结构表征。通过该综合化学实验的教学实施，引导学生能结合科学前沿特别是I2/DMSO组合试剂体系介导下芳基甲酮作为起始原料合成天然产物，从而实现有机化学合成实验的绿色化，加深对并环化合物的认识，激发学生独立思考和创新意识，有利于新工科背景下应用型人才的培养。

关键词: 绿色有机合成, 综合化学实验, Fascaplysin类生物碱, I2/DMSO体系

Abstract:

We introduce a comprehensive chemistry experiment, namely "Nomenclature, synthesis, and characterization of fascaplysin alkaloids". The experiment involves the nomenclature, preparation, separation, purification, and characterization of fused-ring fascaplysin alkaloids. During the experiment, frontier scientific tools, especially the I2/DMSO combination reagent system, were used to synthesize natural products such as fascaplysin alkaloids starting from aryl ketones to realize green organic chemical synthesis experiments. This approach deepens the understanding of fused ring compounds, stimulates independent thinking and innovation consciousness in students, and could be conducive for cultivating application-oriented talents in emerging engineering.

Key words: Green organic synthesis, Comprehensive chemistry experiment, Fascaplysin Alkloids, I2/DMSO system