关键词: 光化学合成, 二氟吡咯烷, 氮杂环, 绿色化学

Abstract: Photochemical synthesis technology has gained attention in the field of synthetic chemistry due to its mild reaction conditions, simple equipment, and utilization of light energy. However, photochemical synthesis experiments are rarely incorporated into undergraduate organic chemistry laboratory courses. Fluorine-containing nitrogen heterocycles are widely present in natural products and bioactive molecules, serving as important intermediates in organic synthesis. Based on our team’s recent research achievements, a comprehensive experiment for the photochemical synthesis of difluoropyrroles has been designed. This experiment encompasses the preparation of substrates and products, structural characterization, and analysis of photochemical synthesis. It aims to enhance students’ skills in organic synthesis and structural analysis, while also sparking their interest in organic chemistry experiments. Furthermore, it plays a significant role in cultivating students’ innovative consciousness and promoting the concept of “green synthesis” by incorporating scientific research outcomes into organic chemistry laboratory teaching.

Key words: Photochemical synthesis, Difluoropyrroles, Nitrogen heterocycle, Green chemistry