如何根据外观辨识单一手性晶体？

doi:10.3866/PKU.DXHX202309004

大学化学 >> 2024, Vol. 39 >> Issue (3): 78-85.doi: 10.3866/PKU.DXHX202309004

所属专题：晶体化学教学

如何根据外观辨识单一手性晶体？

王海英¹^,*(), 苏纪豪²

¹ 川北医学院医学影像四川省重点实验室, 四川南充 637000
² 厦门大学化学化工学院, 福建厦门 361005

收稿日期:2023-09-01 录用日期:2023-10-19 发布日期:2023-11-13
通讯作者: 王海英 E-mail:hywang@nsmc.edu.cn

How to Visually Identify Homochiral Crystals

Haiying Wang¹^,*(), Andrew C.-H. Sue²

¹ Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
² College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian Province, China

Received:2023-09-01 Accepted:2023-10-19 Published:2023-11-13
Contact: Haiying Wang E-mail:hywang@nsmc.edu.cn

摘要/Abstract

摘要：

有些消旋体结晶过程中的自发拆分会导致对映异构体单晶呈现不同的外观状态。本文总结并列举了根据外观辨识单一手性晶体的四种方式，包括：半面体面、宏观形态、偏光颜色和表面形貌。这些“以貌取人”的方法为探究手性化合物的结晶行为提供了重要的工具和见解。

关键词: 自发拆分, 半面体面, 宏观形态, 偏光颜色, 表面形貌

Abstract:

During the crystallization process of certain racemic compounds, spontaneous resolution can lead to distinctive external appearances of enantiomeric crystal forms. This article offers a comprehensive overview and delineates four methods for identification, namely, examining hemihedral faces, assessing macromorphology, employing circular polarization, and analyzing surface topography. These identification techniques serve as invaluable tools and viewpoints for studying the crystallization behavior of chiral compounds, holding significant potential across diverse applications in pharmaceutical production, materials science, and chemical synthesis.

Key words: Spontaneous resolution, Hemihedral faces, Macromorphology, Circular polarization, Surface topography

王海英, 苏纪豪. 如何根据外观辨识单一手性晶体？[J]. 大学化学, 2024, 39(3): 78-85.

Haiying Wang, Andrew C.-H. Sue. How to Visually Identify Homochiral Crystals[J]. University Chemistry, 2024, 39(3): 78-85.

链接本文: https://www.dxhx.pku.edu.cn/CN/10.3866/PKU.DXHX202309004

https://www.dxhx.pku.edu.cn/CN/Y2024/V39/I3/78

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晶系	空间群
立方	P23, P2₁3, I23, I2₁3, F23, P432, (P4₁32, P4₃32), P4₂32, I432, I4₁32, F432, F4₁32
四方晶系	P4, (P4₁, P4₃), P4₂, I4, I4₁, P422, P42₁2, (P4₁22, P4₃22), (P4₁2₁2, P4₃2₁2), P4₂22, P4₂2₁2, I422, I4₁22
单斜晶系	P2, P2₁, C2
斜方晶系	P222, P222₁, P2₁2₁2, P2₁2₁2₁, C222, C222₁, I222, I2₁2₁2₁, F222
三斜晶系	P1
三方晶系	P3, (P3₁, P3₂), P312, P321, (P3₁12, P3₂12), (P3₁21, P3₂21), R3, R32
六方晶系	P6, (P6₁, P6₅), (P6₂, P6₄), P6₃, P622, (P6₁22, P6₅22), P6₃22, (P6₂22, P6₄22)

晶系	点群	条件
三斜晶系	(1)	无限制条件
单斜晶系	(2)	h and/or l ⊂ Z^{* a}, k ⊂ Z^* (second setting)
斜方晶系	(2 2 2)	h and k and l ⊂ Z^*
四方晶系	(4), (4 2 2)	h and k and l ⊂ Z^*, (h ≠ k)
三方晶系	(3), (3 2)	h and k and l ⊂ Z^*, (h ≠ k)
六方晶系	(6), (6 2 2)	h and k and l ⊂ Z^*, (h ≠ k)
立方晶系	(2 3), (4 3 2)	h and k and l ⊂ Z^, (h ≠ k, k ≠ l, l ≠ h*)

[1]	章慧. 降压药尼莫地平的前世今生[J]. 大学化学, 2018, 33(7): 43 -55 .
[2]	章慧, 林丽榕. 配位化学中的镜面对称性破缺——纪念配位化学创始人维尔纳首次拆分八面体Co(Ⅲ)络合物100周年[J]. 大学化学, 2011, 26(6): 8 -15 .

如何根据外观辨识单一手性晶体？

How to Visually Identify Homochiral Crystals

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