大学化学 >> 2025, Vol. 40 >> Issue (11): 184-190.doi: 10.12461/PKU.DXHX202412054

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探寻Petasis-硼酸-Mannich反应的奥秘

蔡美慧, 黄熠, 马星星, 宋秋玲   

  1. 福州大学化学学院, 福州 350108
  • 收稿日期:2024-12-11 录用日期:2025-04-15 发布日期:2025-11-21
  • 通讯作者: 马星星, 宋秋玲 E-mail:maxx@fzu.edu.cn;qsong@fzu.edu.cn Xingxing Ma, Qiuling Song
  • 基金资助:
    污染物分析与资源化技术湖北省重点实验室开放基金重点项目(PA240102)；福建省自然科学基金(2022J02009,2022J05016)

Exploring the Mysteries of the Petasis-Boronic Acid-Mannich Reaction

Meihui Cai, Yi Huang, Xingxing Ma, Qiuling Song   

  1. College of Chemistry, Fuzhou University, Fuzhou 350108, China
  • Received:2024-12-11 Accepted:2025-04-15 Published:2025-11-21
  • Contact: Xingxing Ma, Qiuling Song E-mail:maxx@fzu.edu.cn;qsong@fzu.edu.cn

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摘要： 本文聚焦于Petasis-硼酸-Mannich反应，系统阐述其起源、反应机理、研究进展及其在有机合成中的应用。该反应作为有机硼化学领域的重要反应，为传统Mannich反应提供了创新性的拓展，丰富了大学有机化学教学内容。通过对Petasis-硼酸-Mannich反应的介绍，有助于学生在掌握经典Mannich反应知识的基础上，激发对有机硼化学领域的学习兴趣与探索热情。

关键词: Petasis反应, 有机硼酸, 多组分反应, 烯丙基胺, 苄基胺

Abstract: This review provides a comprehensive examination of the Petasis-boronic acid-Mannich reaction, systematically elucidating its origin, reaction mechanism, research progress, and applications in organic synthesis. As a significant advancement in organoboron chemistry, this reaction represents an innovative extension of the traditional Mannich reaction and contributes to the enrichment of university-level organic chemistry curricula. By introducing the Petasis-boronic acid-Mannich reaction, this work aims to enhance students’ understanding of advanced organic reactions while fostering their interest and enthusiasm for exploring the field of organoboron chemistry, building upon their foundational knowledge of the classical Mannich reaction.

Key words: Petasis reaction, Organoboronic acid, Multicomponent reaction, Allylamine, Benzylamine