大学化学 >> 2025, Vol. 40 >> Issue (5): 376-382.doi: 10.12461/PKU.DXHX202411055

化学实验 上一篇    下一篇

绿色制药背景下的安息香氧化实验教学改革

罗美虹, 王洪玉   

  1. 中国海洋大学医药学院, 山东 青岛 266003
  • 收稿日期:2024-11-19 修回日期:2025-01-23 发布日期:2025-05-21
  • 通讯作者: 王洪玉 E-mail:why@ouc.edu.cn
  • 基金资助:
    国家自然科学基金-面上项目(22377113)；中国海洋大学本科教育教学研究项目(2024JY069)

Teaching Reform of Benzoin Oxidation Experiment in the Context of Green Pharmaceutical Chemistry

Meihong Luo, Hongyu Wang   

  1. School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, Shandong Province, China
  • Received:2024-11-19 Revised:2025-01-23 Published:2025-05-21
  • Contact: Hongyu Wang E-mail:why@ouc.edu.cn

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摘要： 绿色有机化学合成设计已成为有机合成和制药领域的重点发展方向，本文基于绿色化学发展理念，设计了以空气中的氧气作为氧化剂、10-甲基-9-均三甲苯基吖啶高氯酸盐为光敏剂、三乙烯二胺为碱、三氯甲烷为溶剂，在456 nm波长下反应2 h，高效实现光催化安息香氧化制备二苯乙二酮，并将其应用于本科教学实验中，实现了科教融合。

关键词: 绿色有机化学, 光催化, 安息香氧化, 本科教学实验

Abstract: Green chemistry has emerged as a pivotal focus in organic synthesis and pharmaceutical development. This paper introduces a photocatalytic benzoin oxidation experiment grounded in green chemistry principles. The experiment utilizes oxygen from the air as the oxidant, 9-mesityl-10-methylacridinium perchlorate as the photocatalyst, triethylenediamine as the base, and chloroform as the solvent, subjected to irradiation by a 456 nm LED for 2 h. By optimizing the experimental conditions, we established the optimal reaction parameters, which were subsequently implemented in undergraduate laboratory courses, thereby integrating scientific research with education.

Key words: Green organic chemistry, Photocatalysis, Benzoin oxidation, Undergraduate teaching experiment