大学化学 >> 2025, Vol. 40 >> Issue (6): 276-285.doi: 10.12461/PKU.DXHX202406013

化学实验 上一篇    下一篇

共价有机框架整体材料的制备及食品安全非靶向筛查应用——推荐一个仪器分析综合化学实验

李薇1, 许锦帆2, 张拥军1, 关英2   

  1. 1 天津工业大学药学院, 天津 300387;
    2 南开大学化学学院, 天津 300071
  • 收稿日期:2024-06-11 录用日期:2024-08-15 发布日期:2025-06-20
  • 通讯作者: 李薇, 关英 E-mail:liw@tiangong.edu.cn;yingguan@nankai.edu.cn
  • 基金资助:
    国家自然科学基金(52033004)；国家自然科学基金(52273109)；国家自然科学基金(52073146)

Preparation of Covalent Organic Framework Monolithic Material for Non-Targeted Food Safety Screening: A Recommended Comprehensive Instrumental Analysis Chemistry Experiment

Wei Li1, Jinfan Xu2, Yongjun Zhang1, Ying Guan2   

  1. 1 College of Pharmacy, Tiangong University, Tianjin 300387, China;
    2 College of Chemistry, Nankai University, Tianjin 300071, China
  • Received:2024-06-11 Accepted:2024-08-15 Published:2025-06-20
  • Contact: LI Wei, GUAN Ying E-mail:liw@tiangong.edu.cn;yingguan@nankai.edu.cn

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摘要： 推荐了一个以实际应用为导向的本科生仪器分析综合实验：以食品安全非靶向筛查为情景，制备了三聚氰胺海绵(MF)与共价有机框架(COF)复合的整体材料(MF@COF)，将其应用于食品非靶向筛查的样品前处理过程。COF通过原位生长键合在廉价易得的MF表面，能有效净化食品基质并回收化学危害因子，同时避免二次污染。实验包含MF@COF材料的制备和表征、吸附植物色素基质、化学危害因子加标回收等内容，以及实验课后数据处理和模型分析。实验立足于席夫碱反应、吸附等温线、动力学等基础知识，加强学生对紫外-可见分光光度法的应用能力，又引入COFs材料的科研前沿，同时结合食品安全检测的实际应用，兼具基础性、综合性和趣味性。通过实验培养学生的创新思维和实践能力，也增强学生对分析化学的兴趣和认同感。

关键词: 共价有机框架, 食品安全, 吸附, 综合化学实验

Abstract: This study recommends a practical, application-oriented comprehensive experiment in instrumental analysis for undergraduate students. Centered on non-targeted food safety screening, a covalent organic framework (COF)-based monolithic material (MF@COF composite) with melamine foam (MF) as the supporter was prepared and applied to sample pretreatment process of non-targeted analysis for food. The COF is in-situ grown and bonded onto the surface of the inexpensive and readily available MF, enabling effective purification of food matrices and complete recovery of chemical hazards while preventing secondary contamination. The experiment encompasses the synthesis and characterization of MF@COF, adsorption of phytochrome, recovery of chemical hazards, as well as post-experimental data processing and model analysis. Grounded in fundamental concepts such as Schiff base reaction, adsorption isotherm, and kinetics, the experiment strengthens students’ proficiency in UV-visible spectrophotometry, introduces the scientific research frontier of COF materials, and integrates real-world applications in food safety analysis. Combining fundamental knowledge with comprehensive and engaging experimental design, the experiment fosters students’ innovative thinking and practical skills while enhancing their interest and confidence in analytical chemistry.

Key words: Covalent organic framework, Food safety, Adsorption, Comprehensive chemistry experiment