关键词: 胶体粒子, 姜黄素, 药物释放, 化学动力学方程

Abstract: To improve pharmacy undergraduates' understanding and application of colloid chemistry and chemical kinetics while addressing the lack of innovation and engagement in traditional physical chemistry experiments, we developed a teaching experiment involving the preparation of curcumin/copper colloidal nanoparticles and their drug release kinetics. This experiment combines scientific education with ideological elements to enhance students' ability to integrate theoretical knowledge with practical skills. Using coordination bonding and self-assembly techniques, we synthesized well-dispersed drug/metal colloidal nanoparticles with uniform particle sizes. The nanoparticles were characterized by transmission electron microscopy, dynamic light scattering, and UV-Vis spectrophotometry to determine their size distribution, surface charge, UV-Vis absorption peaks, pH-dependent controlled release properties, and free radical generation capacity. This open-ended experimental design not only strengthens student' ability to connect theory with practice but also stimulates their interest through interdisciplinary research, effectively bridging fundamental teaching with scientific training to cultivate innovative pharmaceutical professionals.

Key words: Colloidal nanoparticles, Curcumin, Drug release, Chemical kinetics equation