大学化学 >> 2024, Vol. 39 >> Issue (6): 226-230.doi: 10.3866/PKU.DXHX202310095

知识介绍 上一篇    下一篇

协同芳香亲核取代反应

林文涛, 王文峰, 袁耀锋, 徐春发   

  1. 福州大学化学学院, 福州 350108
  • 收稿日期:2023-10-25 修回日期:2024-01-09 发布日期:2024-06-07
  • 通讯作者: 王文峰, 袁耀锋, 徐春发 E-mail:xucf@email.com;yaofeng_yuan@fzu.edu.cn;wangwf@fzu.edu.cn
  • 基金资助:
    教育部2022年度基础学科拔尖计划2.0研究课题(20222114)；国家自然科学基金(83422104)

Concerted Nucleophilic Aromatic Substitution Reactions

Wentao Lin, Wenfeng Wang, Yaofeng Yuan, Chunfa Xu   

  1. College of Chemistry, Fuzhou University, Fuzhou 350108, China
  • Received:2023-10-25 Revised:2024-01-09 Published:2024-06-07
  • Contact: Wenfeng Wang, Yaofeng Yuan, Chunfa Xu E-mail:xucf@email.com;yaofeng_yuan@fzu.edu.cn;wangwf@fzu.edu.cn

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摘要： 芳香亲核取代反应被有机化学家广泛地用于有机化合物的合成，是最重要的合成反应之一。教材中对于该反应机理的介绍为分步过程，但是随着研究的深入，通过协同过程的芳香亲核取代反应已经被广泛证实。本文简要回顾了分步进行的芳香亲核取代反应，重点介绍了协同芳香亲核取代反应的几个实例，阐述了反应设计对机理研究的重要性。通过将科研成果融入教学过程，有助于进一步加深对芳香亲核取代反应的理解。

关键词: 芳香亲核取代反应, 协同, 分步, 反应机理

Abstract: Nucleophilic aromatic substitution reactions play a crucial role in the synthesis of organic compounds and are considered to be one of the most important synthetic transformations. Traditionally, these reactions have been described as stepwise processes in textbooks. However, with further research, the existence of concerted nucleophilic aromatic substitution reactions has been widely confirmed. This paper provides a brief overview of the stepwise pathway of nucleophilic aromatic substitution reactions and focuses on several examples of concerted reactions, highlighting the importance of reaction design in mechanistic studies. Integrating cutting-edge research findings into teaching can enhance students’ understanding of nucleophilic aromatic substitution reactions.

Key words: Nucleophilic aromatic substitution reaction, Concerted, Stepwise, Reaction mechanism