大学化学 >> 2024, Vol. 39 >> Issue (9): 35-39.doi: 10.12461/PKU.DXHX202401027

所属专题： 化学科普(2024)

科普 上一篇    下一篇

奇迹女侠NAD+——烟酰胺腺嘌呤二核苷酸

李玫瑾1,2, 傅熙容1,2, 郑雪1,2, 刘语涵1,2, 李宝1   

  1. 1 华中科技大学化学与化工学院, 武汉 430074;
    2 华中科技大学同济医学院基础医学院, 武汉 430074
  • 收稿日期:2024-01-08 修回日期:2024-03-07 发布日期:2024-09-23
  • 通讯作者: 李宝 E-mail:libao@hust.edu.cn
  • 基金资助:
    湖北本科高校省级教学改革研究项目(2023040)；国家自然科学基金(92161123)

The Marvel of NAD+: Nicotinamide Adenine Dinucleotide

Meijin Li1,2, Xirong Fu1,2, Xue Zheng1,2, Yuhan Liu1,2, Bao Li1   

  1. 1 School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China;
    2 School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China
  • Received:2024-01-08 Revised:2024-03-07 Published:2024-09-23
  • Contact: Bao Li E-mail:libao@hust.edu.cn

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摘要： NAD+(烟酰胺腺嘌呤二核苷酸)是一种重要的生物分子，它在细胞内起着关键的能量传递和代谢调控作用。近年来，NAD+在医学和健康领域的研究备受关注，尤其是在衰老、代谢疾病和癌症治疗方面，与它相关的食物也逐渐变成了当代人们餐桌上的新宠。本文用拟人化的口吻介绍了NAD+的化学结构、生物功能以及与健康相关的最新研究发展，分析了它从抗衰老领域转型临床运用的潜力。

关键词: NAD+性质, 氧化还原, 抗衰老, 炎症免疫, 疾病治疗

Abstract: Nicotinamide adenine dinucleotide (NAD+) is a pivotal biological molecule with essential roles in cellular energy transfer and metabolic regulation. In recent years, research on NAD+ in the medical and health domains has garnered significant attention, particularly concerning aging, metabolic disorders, and cancer treatment. Foods associated with NAD+ are gradually becoming popular choices on contemporary dining tables. This article, adopting a personified tone, presents the chemical structure, biological functions, and the latest research advancements pertaining to NAD+, while also assessing its potential transition from the realm of anti-aging to clinical applications.

Key words: NAD+ nature, Redox, Anti-aging, Inflammation immunity, Disease treatment