大学化学 >> 2025, Vol. 40 >> Issue (6): 341-352.doi: 10.12461/PKU.DXHX202406018

所属专题： 高水平创新型药学人才培养与化学课程教学

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生物化学在高水平创新型药学人才培养中的交叉融合应用——以去甲基化酶LSD1抑制剂的活性评价为例

宋宜辉1, 秦上尚1, 吴凯1, 金成允1, 余斌2   

  1. 1 郑州大学药学院, 郑州 450001;
    2 郑州大学化学学院, 平原实验室, 抗病毒性传染病创新药物全国重点实验室, 郑州 450001
  • 收稿日期:2024-06-11 录用日期:2024-08-14 发布日期:2025-06-20
  • 通讯作者: 余斌, 金成允 E-mail:yubin@zzu.edu.cn;cyjin@zzu.edu.cn
  • 基金资助:
    郑州大学教育教学改革研究与实践项目(2023ZZUJGXW226)；河南省本科高校校级青年骨干教师培养计划；河南省本科高校省级青年骨干教师培养计划(2021GGJS016)

Cross-Integration Application of Biochemistry in the Cultivation of High-Level Innovative Pharmaceutical Talents: A Case Study on the Activity Evaluation of Demethylase LSD1 Inhibitors

Yihui Song1, Shangshang Qin1, Kai Wu1, Chengyun Jin1, Bin Yu2   

  1. 1 School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China;
    2 State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, College of Chemistry, Zhengzhou University, Zhengzhou 450001, China
  • Received:2024-06-11 Accepted:2024-08-14 Published:2025-06-20
  • Contact: YU Bin, JIN Chengyun E-mail:yubin@zzu.edu.cn;cyjin@zzu.edu.cn

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摘要： 药学是一门综合性学科，涉及生物学、化学、医学等多个领域。作为连接生物学和化学的桥梁，生物化学是药学教育中的一门基础必修课程，对于培养高水平创新型药学人才具有重要意义。但生物化学各章节相对独立，理论知识点繁多且零散，学生理解学习和灵活应用难度较大。如何有效地将生物化学基础理论知识与药学实践交叉应用，培养出具有创新能力和实践技能的药学人才是当前药学教育教学改革的重要课题。本文以去甲基化酶LSD1抑制剂的活性评价为例，采用传统理论教学与案例教学相结合的教学模式有机地将生物化学的理论知识与药物研发过程系统联系起来，激发学生的学习兴趣，培养学生的科研创新精神。本文旨在探讨闭环式案例教学模式在生物化学与药学教育中的融合应用，培养学生的分析思维能力和问题解决能力，引导他们运用生物化学知识分析和解决药物研发中的实际问题，以期为我国高水平创新型药学人才培养提供参考和借鉴。

关键词: 生物化学, 药学人才培养, 闭环式案例教学, 融合应用, 科研创新

Abstract: Pharmacy is a multidisciplinary field that encompasses biology, chemistry, and medicine. Serving as a fundamental bridge connecting biology and chemistry, biochemistry is a core course in pharmaceutical education and plays a crucial role in cultivating high-level innovative pharmaceutical talents. However, it is traditionally taught in independent chapters with extensive and fragmented theoretical content, making it challenging for students to comprehend and apply flexibly. Effectively integrating fundamental biochemistry theory with pharmaceutical practice to cultivate innovative and practically skilled pharmaceutical professionals is a key topic in the ongoing reform of pharmaceutical education. This study uses activity evaluation of demethylase LSD1 inhibitors as an example and adopts a hybrid teaching model that combines traditional theoretical instruction with case-based teaching. By systematically linking biochemical concepts with the drug development process, this approach enhances students’ engagement, fosters scientific research and innovation, and improves their ability to analyze and solve practical problems in drug discovery. This study explores the application of a closed-loop case-based teaching model in integrating biochemistry and pharmaceutical education, aiming to enhance students’ analytical thinking and problem-solving ability. The findings provide valuable insights for the development of high-level innovative pharmaceutical talent.

Key words: Biochemistry, Pharmaceutical talent training, Closed-loop case-based education, Integrated application, Research innovation