大学化学 >> 2026, Vol. 41 >> Issue (7): 161-167.doi: 10.12461/PKU.DXHX202504008

科普 上一篇    

毒品江湖

陈肯, 马梓然, 沈珍, 陈建成   

  1. 南京大学化学化工学院, 江苏 南京 210023
  • 收稿日期:2025-04-01 录用日期:2025-06-10 发布日期:2026-06-27
  • 通讯作者: 陈建成 E-mail:kschan@nju.edu.cn Kin Shing Chan
  • 基金资助:
    南京大学百位名师邀约项目;南京大学短期国外专家项目

The war against drugs

Ken Chen, Ziran Ma, Zhen Shen, Kin Shing Chan   

  1. School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, Jiangsu Province, China
  • Received:2025-04-01 Accepted:2025-06-10 Published:2026-06-27
  • Contact: Kin Shing Chan E-mail:kschan@nju.edu.cn

摘要: 纵观江湖,“毒帮”为祸一方,凭借成瘾、致幻、麻醉等神功欺凌百姓,将一批批瘾君子拖入毒瘾之泥沼。为根除毒帮,还江湖浩然正气,一支毒品讨伐队各显神通,掀起一场禁毒战争。讨伐队成员们利用化学与生物知识,参透毒品的成瘾机制,制造长效阿片类药物反击海洛因等阿片类毒品;巧借酶的过渡态稳定学说,合成抗体酶水解可卡因;利用免疫系统,制作可卡因疫苗。毒品讨伐队取得了抗击毒帮的大胜,但面对层出不穷的新型毒品,讨伐队一直在路上。

关键词: 毒品, 长效阿片类药物, 抗体酶, 疫苗, 成瘾性

Abstract: In the martial world, the notorious “Drug Sect” spreads chaos through their nefarious arts of addiction, hallucination, and narcosis, dragging countless victims into the abyss of substance dependence. To eradicate this threat and restore righteousness, an Anti-drug Crusader Squad has risen to wage war against the Drug Sect. Leveraging chemical and biological expertise, the crusaders have deciphered addiction mechanisms to develop long-acting opioid therapies against heroin and other opioids. Employing enzyme transition-state theory, they engineered catalytic antibodies for cocaine hydrolysis. Furthermore, they developed a cocaine vaccine by harnessing the immune system. While achieving significant victories against the Drug Sect, the crusaders remain vigilant as new synthetic drugs continue to emerge.

Key words: Drugs, Long-acting opioid therapy, Catalytic antibody, Vaccine, Addiction