大学化学 >> 2026, Vol. 41 >> Issue (5): 180-189.doi: 10.12461/PKU.DXHX202509129

所属专题： 第5届全国大学生化学实验创新设计大赛

专题 上一篇    

聚光捕胺——高灵敏胺响应型聚集诱导发光探针的合成及传感应用

吴昕蓉, 任盈盈, 王建雪, 杨丽锦, 贾佳, 李楠, 赵娜   

  1. 陕西师范大学化学化工学院, 陕西 西安 710119
  • 收稿日期:2025-09-29 录用日期:2026-01-30 发布日期:2026-05-21
  • 通讯作者: 李楠, 赵娜 E-mail:nli@snnu.edu.cn;nzhao@snnu.edu.cn Nan Li, Na Zhao
  • 基金资助:
    陕西师范大学中央高校创新团队项目(GK202502006)

Amine-trapping glow: synthesis and sensing applications of a highly sensitive amine-responsive aggregation-induced emission probe

Xinrong Wu, Yingying Ren, Jianxue Wang, Lijin Yang, Jia Jia, Nan Li, Na Zhao   

  1. School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710119, Shaanxi Province, China
  • Received:2025-09-29 Accepted:2026-01-30 Published:2026-05-21
  • Contact: Nan Li, Na Zhao E-mail:nli@snnu.edu.cn;nzhao@snnu.edu.cn

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摘要： 本论文将聚集诱导发光(AIE)前沿成果转化为本科教学实践，构建了一个8学时综合化学实验。实验合成与表征了喹唑啉衍生物2-(2-羟基苯基)喹唑啉-4(3H)-酮(HPQ)和2-[2-(乙酰基)苯基]喹唑啉-4(3H)-酮(APQ)，探究了HPQ的AIE特性及APQ对胺蒸气的荧光响应特性，并拓展至隐形墨水与肉类新鲜度检测等实际应用。该实验通过直观现象和实际应用激发学生科研兴趣，系统训练合成、表征及科研思维，有效提升专业素质与创新能力。

关键词: 聚集诱导发光, 荧光探针, 胺蒸气, 喹唑啉衍生物, 荧光传感

Abstract: This work bridges cutting-edge aggregation-induced emission (AIE) research with undergraduate education by developing an 8-hour comprehensive chemistry experiment. The laboratory exercise encompasses the synthesis and characterization of quinazoline derivatives 2-(2-hydroxyphenyl)quinazolin-4(3H)-one (HPQ) and 2-(2-(acetyl)phenyl)quinazolin-4(3H)-one (APQ), examination of HPQ’s AIE characteristics, and evaluation of APQ’s fluorescence response to amine vapors. The practical applications extend to invisible ink development and meat freshness detection. By demonstrating observable phenomena and real-world applications, this experiment effectively engages students’ research interests while systematically developing their synthetic skills, characterization techniques, and scientific reasoning abilities, thereby enhancing both professional competency and innovative capacity.

Key words: Aggregation-induced emission, Fluorescent probe, Amine vapor, Quinazoline derivative, Fluorescent sensing