大学化学 >> 2026, Vol. 41 >> Issue (5): 358-367.doi: 10.12461/PKU.DXHX202510007

所属专题： 第5届全国大学生化学实验创新设计大赛

专题 上一篇    

可见光催化绿色合成二肽化合物

艾晓梅1, 林牧然1, 曾金兰1, 任继伟1,2   

  1. 1 泰山学院化学化工学院, 山东 泰安 271000;
    2 曲阜师范大学化学与化工学院, 山东 曲阜 273165
  • 收稿日期:2025-10-09 录用日期:2026-02-06 发布日期:2026-05-21
  • 通讯作者: 任继伟 E-mail:renjiwei@tsu.edu.cn Jiwei Ren
  • 基金资助:
    国家自然科学基金项目(22508288)；山东省自然科学基金项目(ZR2023QB153)

Visible light catalysis for green synthesis of dipeptides

Xiaomei Ai1, Muran Lin1, Jinlan Zeng1, Jiwei Ren1,2   

  1. 1 College of Chemistry and Chemical Engineering, Taishan University, Tai'an 271000, Shandong Province, China;
    2 School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong Province, China
  • Received:2025-10-09 Accepted:2026-02-06 Published:2026-05-21
  • Contact: Jiwei Ren E-mail:renjiwei@tsu.edu.cn

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摘要： 本文报道了一种可见光催化三苯基膦促进的脱氧酰胺化策略，用于二肽化合物的合成。以金属铱的配合物为催化剂，在蓝光照射下N-保护的氨基酸产生酰基自由基，和氨基酸酯发生偶联反应生成二肽，产物具有较高的产率和非常好的非对映选择性。实验具有试剂廉价易得、反应条件温和、操作简单安全、绿色高效、重现性好等优点，时间可控制在8学时内。

关键词: 可见光催化, 二肽, 脱氧酰胺化, 金属铱配合物, 三苯基膦

Abstract: This study presents a visible-light-induced photocatalytic strategy employing triphenylphosphine-promoted deoxygenative amidation for dipeptide synthesis. Utilizing an iridium metal complex as the catalyst under blue light irradiation, N-protected amino acids generate acyl radicals that subsequently couple with amino acid esters to form dipeptides. The method demonstrates high product yields and exceptional diastereoselectivity. This protocol features cost-effective reagents, mild reaction conditions, operational simplicity, environmental friendliness, high efficiency, and excellent reproducibility, with the entire process completable within an 8-hour timeframe.

Key words: Visible light catalysis, Dipeptide, Deoxygenative amidation, Iridium complex, Triphenylphosphine