大学化学 >> 2026, Vol. 41 >> Issue (5): 350-357.doi: 10.12461/PKU.DXHX202510080

所属专题： 第5届全国大学生化学实验创新设计大赛

专题 上一篇    

维生素B2促进的光催化氧化合成二苯甲酮

郝志强, 李金悦, 张诗琪, 侯雨佳, 孙贺略   

  1. 河北师范大学化学与材料科学学院, 化学国家级实验教学示范中心(河北师范大学), 河北 石家庄 050024
  • 收稿日期:2025-10-21 录用日期:2026-02-26 发布日期:2026-05-21
  • 通讯作者: 郝志强, 孙贺略 E-mail:zqhao@hebtu.edu.com;heluesun@hebtu.edu.cn Zhiqiang Hao, Helue Sun
  • 基金资助:
    河北师范大学研究生创新资助项目(XCXZZBS202545)；河北省高等教育教学改革研究与实践项目(2025GJJG149)

Photocatalytic oxidation synthesis of benzophenone promoted by vitamin B2

Zhiqiang Hao, Jinyue Li, Shiqi Zhang, Yujia Hou, Helue Sun   

  1. National Experimental Chemistry Teaching Center, College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024, Hebei Province, China
  • Received:2025-10-21 Accepted:2026-02-26 Published:2026-05-21
  • Contact: Zhiqiang Hao, Helue Sun E-mail:zqhao@hebtu.edu.com;heluesun@hebtu.edu.cn

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摘要： 二苯甲酮的制备是现行本科化学实验教材中的一个重要的有机合成实验，但传统合成方法需要使用大量氧化剂，使用毒性较大的苯作为原料，以及存在操作复杂等问题。基于绿色化学发展理念，本改进实验将光催化合成技术引入至二苯甲酮制备的实验当中，以维生素B2 (核黄素)作为光催化剂，利用空气中的氧气作为氧化剂，在可见光照射下催化二苯甲烷氧化制备二苯甲酮。该改进方法无需金属催化剂，反应条件温和，操作简单，成本低廉，将光化学合成的前沿理念和技术融入本科生实验教学中，为本科实验教学提供了一种安全高效、创新环保的实验案例。这不仅促进了学生对光催化反应和绿色化学的理解，也有助于学生创新能力的培养和科学思维的引导。

关键词: 光催化氧化, 维生素B2, 二苯甲酮, 绿色化学

Abstract: The synthesis of benzophenone represents a fundamental organic chemistry experiment in current undergraduate laboratory curricula. However, conventional methods suffer from several drawbacks, including the requirement for excessive oxidizing agents, the use of highly toxic benzene as starting material, and complex operational procedures. Aligned with green chemistry principles, this modified experiment incorporates photocatalytic synthesis technology for benzophenone production, employing vitamin B2 (riboflavin) as a photocatalyst and molecular oxygen from air as the oxidant under visible light irradiation. The improved protocol eliminates the need for metal catalysts while offering advantages of mild reaction conditions, operational simplicity, and cost-effectiveness. By integrating cutting-edge photochemical synthesis concepts into undergraduate laboratory education, this approach provides a safe, efficient, and environmentally benign experimental model. The experiment not only deepens students’ understanding of photocatalytic reactions and green chemistry principles, but also fosters innovative thinking and cultivates scientific reasoning skills.

Key words: Photocatalytic oxidation, Vitamin B2, Benzophenone, Green chemistry