大学化学 >> 2026, Vol. 41 >> Issue (9): 257-263.doi: 10.12461/PKU.DXHX202509042

科普 上一篇    下一篇

细胞化学重编程：时光机里的细胞精灵

陈蓉1, 王煜媛2, 易婧妍2, 李媛3, 郭凯2   

  1. 1 西南医科大学临床医学院, 四川 泸州 646000;
    2 西南医科大学基础医学院, 四川 泸州 646000;
    3 昆明理工大学学报编辑部, 云南 昆明 650500
  • 收稿日期:2025-09-10 录用日期:2025-11-26 发布日期:2026-09-01
  • 通讯作者: 郭凯 E-mail:guokai@swmu.edu.cn Kai Guo
  • 基金资助:
    四川省科普培训项目(2024JDKP0126)

Cellular chemical reprogramming: the cellular sprite in the time machine

Rong Chen1, Yuyuan Wang2, Jingyan Yi2, Yuan Li3, Kai Guo2   

  1. 1 Clinical Medical College, Southwest Medical University, Luzhou 646000, Sichuan Province, China;
    2 School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, Sichuan Province, China;
    3 Editorial Department of Journal of Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China
  • Received:2025-09-10 Accepted:2025-11-26 Published:2026-09-01
  • Contact: Kai Guo E-mail:guokai@swmu.edu.cn

PDF

46

赞

摘要： 以青年学子林默的梦境为叙事主线，讲述其在学术失利后邂逅化学诱导多能干细胞精灵CiPS-073，通过时空穿越与科学对话，系统梳理了化学诱导多能干细胞研究的关键突破。细胞精灵带领林默回溯约翰·戈登的非洲爪蟾核移植实验(体细胞分化逆转的开端)，山中申弥团队通过4种转录因子实现诱导多能干细胞(iPSC)的里程碑和隐忧，以及化学小分子替代转录因子的探索。详解化学重编程的分子机制，并重点展现我国邓宏魁团队的突破——利用表观重置剂等小分子组合，跨过胚外内胚层中间状态，显著缩短体细胞重编程时间。文中展望iPSC在神经退行性疾病、心梗修复、糖尿病及老年黄斑治疗中的潜力。通过与细胞精灵的对话，林默直观理解“程序错误”的进化意义，最终领悟科研失败的价值，醒来后以全新姿态投入研究。故事以“失败驱动创新”为核心，鼓励青年学子直面挫折，将科研困境转化为突破契机，兼具科学普及与人生哲理的双重启示。

关键词: 化学诱导多能干细胞, 转录因子, 化学小分子组合, 化学重编程

Abstract: This narrative follows young scholar Lin Mo's dream journey after academic setbacks, where he encounters CiPS-073, a chemically induced pluripotent stem cell sprite. Through temporal exploration and scientific discourse, the story systematically examines key breakthroughs in chemically induced pluripotent stem cell research. The cellular sprite guides Lin Mo through pivotal moments: John Gurdon's nuclear transfer experiments in Xenopus laevis (marking the inception of somatic cell differentiation reversal), Shinya Yamanaka's team's landmark achievement and subsequent concerns regarding induced pluripotent stem cells (iPSCs) using four transcription factors, and the exploration of small molecules as transcription factor alternatives. The narrative elaborates on chemical reprogramming's molecular mechanisms, particularly highlighting the breakthrough by Hongkui Deng's team in China—employing epigenetic reset agents and small molecule combinations to bypass the extraembryonic endoderm intermediate state, significantly reducing somatic cell reprogramming time. The story explores iPSC applications in neurodegenerative diseases, myocardial infarction repair, diabetes treatment, and age-related macular degeneration therapy. Through dialogues with the cellular sprite, Lin Mo gains insight into the evolutionary significance of “program errors” and ultimately recognizes the value of scientific failure, awakening with renewed determination. Centered on the theme “failure drives innovation”, the story encourages young scholars to transform research challenges into opportunities, offering dual enlightenment in scientific literacy and life philosophy.

Key words: Chemically induced pluripotent stem cells, Transcription factors, Combination of chemical small molecules, Chemical reprogramming