大学化学 >> 2026, Vol. 41 >> Issue (6): 152-159.doi: 10.12461/PKU.DXHX202511100

所属专题： 化学“101计划”案例

专题 上一篇    

化学“101计划”合成化学实验课程建设——L-脯氨酸催化的不对称Aldol缩合反应实验教学设计与实践

吴韶华, 鄢剑锋, 徐春发, 李远明, 杨凯, 林彩霞   

  1. 福州大学化学学院, 福建 福州 350116
  • 收稿日期:2025-11-17 录用日期:2026-01-05 发布日期:2026-06-18
  • 通讯作者: 吴韶华 E-mail:wsh@fzu.edu.cn Shaohua Wu
  • 基金资助:
    福州大学2025年本科教育教学改革研究项目；福州大学2025年开放探索性实验项目；福州大学研究生教育教学改革项目(FYAI2025019)

Construction of the synthetic chemistry experiment course under the Chemistry “101 Plan”: instructional design and implementation of the L-proline-catalyzed asymmetric aldol condensation reaction experiment

Shaohua Wu, Jianfeng Yan, Chunfa Xu, Yuanming Li, Kai Yang, Caixia Lin   

  1. College of Chemistry, Fuzhou University, Fuzhou 350116, Fujian Province, China
  • Received:2025-11-17 Accepted:2026-01-05 Published:2026-06-18
  • Contact: Shaohua Wu E-mail:wsh@fzu.edu.cn

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摘要： “L-脯氨酸催化的不对称Aldol缩合反应”实验是化学“101计划”合成化学实验课程中手性合成模块的实验项目，对应于不对称催化合成方法的教学。该实验将研究前沿“有机小分子催化不对称合成”融入本科实验教学，内容来源于2021年诺贝尔化学奖获得者Benjamin List在2000年发表的经典研究工作。本文详细介绍了该实验教学的设计与实施过程。通过精心教学设计，引导学生在掌握实验基础知识和基本技能的基础上，理解科学发现的逻辑，培养科学探究精神与创新思维，激发科研兴趣，从而提升基础化学学科人才培养质量。

关键词: 化学“101计划”, 合成化学实验, 课程建设, 教学设计, 不对称催化, 诺贝尔化学奖

Abstract: The “L-proline-catalyzed asymmetric Aldol condensation reaction” experiment constitutes a key component of the chiral synthesis module within the Synthetic Chemistry Laboratory Course of the Chemistry “101 Plan”, specifically designed to demonstrate principles of asymmetric catalytic synthesis. This experiment introduces the cutting-edge research area of organocatalytic asymmetric synthesis into undergraduate laboratory education, drawing inspiration from a work reported in 2000 by Benjamin List, who was awarded the 2021 Nobel Prize in Chemistry. This article comprehensively details the experimental design and implementation process. Through carefully structured pedagogy, the experiment enables students to master fundamental knowledge and techniques while fostering an understanding of scientific discovery processes, cultivating investigative skills and innovative thinking, stimulating research interests, and ultimately enhancing the quality of foundational chemistry education.

Key words: Chemistry “101 plan”, Synthetic chemistry laboratory, Course construction, Instructional design, Asymmetric catalysis, Nobel Prize in Chemistry